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糖基转移酶抑制剂研究进展 被引量：6

Advances in Glycosyltransferase Inhibitors
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摘要 糖基转移酶是糖蛋白、糖脂中糖链生物合成的关键酶之一,其活性的非正常表达与肿瘤、免疫系统等疾病的发生、发展有密切关系,其抑制剂可以用于抗肿瘤、抗免疫系统等疾病的新药研发.综述了近年来合成的各类糖基转移酶抑制剂的结构及活性研究进展. Glycosyltransferases play a pivotal role in the biosynthesis of oligosaccharides in glycoproteins and glycolipids. The glycosyltransferase inhibitors have the potential for discovering the drugs of anti-tumor, anti-diseases of immune system, etc. This review presents the recent progress in the study on the structure and biological activity of the synthesized glycosyltransferase inhibitors.
作者 陈华 王东跃 李小六
机构地区 河北大学化学与环境科学院河北省化学生物学重点实验室教育部药物化学与分子诊断省部共建重点实验室 河北农业大学理学院
出处 《有机化学》 SCIE CAS CSCD 北大核心 2009年第5期704-716,共13页 Chinese Journal of Organic Chemistry
基金 国家自然科学基金(Nos.20472015,20672027) 河北省自然科学基金(Nos.2005000106,B2008000588) 教育部科学技术研究重点(No.206013) 国家博士后基金资助项目
关键词 糖基转移酶 抑制剂 抗肿瘤 抗免疫系统疾病 glycosyltransferase inhibitor anti-tumor anti-disease of immune system
分类号 TQ464 [化学工程—制药化工]
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有机化学
2009年 第5期

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