摘要
研究肝病患者ｅ抗原转阴后病毒复制情况以及ＨＢＶ－ＤＮＡ检出率与临床疾病状态的关系。方法采用ＰＣＲ技术对１０８例ｅＡｇ阴性、ＨＢｓＡｇ阳性肝病患者进行血清ＨＢＶ－ＤＮＡ分析，同时进行肝功能指标检测。结果５０．９％的患者体内仍存在乙肝病毒复制。ＨＢＶ－ＤＮＡ阳性无症状携带者２７．８％、慢迁肝４５．８％、慢活肝７７．８％、肝硬化５６．５％、肝癌３７．５％。ＨＢＶ－ＤＮＡ阳性组ＡＬＴ值为１３８．６±１０２．８ＩＵ，而ＨＢＶ－ＤＮＡ阴性组为３４．２±３０．２ＩＵ。结论ｅＡｇ阴性乙肝病毒感染者中仍有相当一部分存在乙肝病毒复制。慢性活动性肝炎患者ＨＢＶ－ＤＮＡ检出率最高。但是疾病发展到晚期，病毒复制能力又开始下降。
Objective In order to study relation between HBVDNA detection rate and different stage of hepatic disease.Methods Serum HBVDNA was investigated from 108 case of different kinds of HBsAgpositive patients with HBeAg(-)by using PCR assay.Results Of the total,509% of patients were found HBVDNA detectable.HBVDNA was found in 278% of asymptomatic HBV carriers,458% in chronic persistent hepatitis ,778% in chronic active hepatitis,565% in liver cirrhosis,375% in heptocelluar carcinoma,respectively.Serum ALT value in HBVDNApositive group was 1386±1028IU,but 342±302IU in HBVDNAnegative group.Conclusion Virus replication exists in HBeAg(-) patients.There is a tendency that the patients with detectable HBVDNA have abnormal liver function.Presence of serum HBVDNA is related with different stage of hepatic disease.
出处
《中国实验诊断学》
1998年第2期70-72,共3页
Chinese Journal of Laboratory Diagnosis
