摘要
本文研究了人参茎叶皂甙对吗啡耐受性产生的影响。实验结果表明，人参茎叶皂甙５０ｍｇ／ｋｇ灌胃给药能够明显对抗吗啡引起的小鼠自主活动增强现象，并抑制吗啡镇痛（小鼠对夹尾压痛）的耐受作用。长期应用吗啡对小鼠体重增长抑制的作用逐渐减弱。人参茎叶皂甙能够加强吗啡抑制体重增长的作用。上述结果提示。
The effect of ginseng stem and leaf saponins (GSLS) on the development of morphine tolerance was studied in mice. The result showed that GSLS, at the dose of 50 mg/kg, p.o. during chronic administration of morphine, significantly inhibited the ambulation accelerating effect of morphine. At the same dose GSLS suppressed the development of tolerance to morphine analgesia as assessed by tail pinch method in mice. The inhibitory effect of morphine on the gain of the body weight was attenuated after chronic administration suggesting the development of tolerance to morphine. GSLS, however, restored the morphines effect by showing a synergic action with morphine to inhibit the gain of the body weight in mice. The above results suggested that GSLS possessed a blocking effect on the development of morphine tolerance in mice.
出处
《中国疼痛医学杂志》
CAS
CSCD
1998年第1期42-47,共6页
Chinese Journal of Pain Medicine
关键词
人参茎叶皂甙
小鼠
吗啡耐受性
镇痛
Ginseng stem and leaf saponins
Morphine
Tolerance
Mouse
