摘要
目的:对多种活血化淤中药的有效组分抑制血小板聚集的作用进行比较。方法:以二磷酸腺苷(ADP)、血小板活化因子(PAF)和胶原为诱导剂,用Born比浊法测定六种中药有效组分对家兔体外血小板聚集的影响,比较各组分的作用强弱和特点。结果:人参皂苷、三七皂苷和红花色素对ADP、PAF和胶原诱导的血小板聚集都有明显的抑制作用,人参皂苷的抑制作用优于其它两种组分;丹参酚酸和葛根黄酮可明显抑制ADP和胶原诱导的血小板聚集,但不影响PAF引起的血小板聚集;麦冬皂苷可明显抑制胶原诱导的血小板聚集,但对ADP和PAF引起的血小板聚集无明显抑制。结论:人参皂苷抑制血小板聚集的作用最强;三七皂苷、人参皂苷和红花色素具有广谱抗血小板聚集作用;丹参酚酸、葛根黄酮及麦冬皂苷各有特点。
AIM：To compare the inhibitory activities of the active ingredients of several traditional Chinese medicines on platelet aggregation.METHODS：The platelet aggregation was tested with Born＇s method,which was induced by ADP,PAF and collagen.The effects on platelet aggregation of six ingredients were evaluated to determine their characteristics.RESULTS：Ginsenosides,panax notoginosides and safflor pigment showed significant inhibitory effects on the aggregation induced by the three drugs;ginsenosides showed the most potent inhibitory activity among them.Salvianolic acids and pueraria flavonoids evidently inhibited the aggregation induced by ADP or collagen,but did not influence PAF-induced platelet aggregation.Ophiopogon japonicus saponins significantly inhibited collagen-induced platelet aggregation,but did not obviously inhibit the aggregation induced by ADP or PAF.CONCLUSION：Ginsenosides showed the most potent inhibitory effect on platelet aggregation among these ingredinents.Panax notoginosides,ginsenosides and safflor pigment displayed extensive inhibitory activities on platelet aggregation.These results provide more information for the clinical selection of Chinese materia medica in the treatment of thrombotic diseases and the development of new Chinese medicine.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2007年第9期1047-1051,共5页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
血小板聚集
丹参酚酸
三七皂苷
人参皂苷
红花色素
麦冬皂苷
葛根黄酮
platelet aggregation
salvianolic acids
panax notoginosides
ginsenosides
safflor pigment
ophiopogon japonicus saponins
pueraria flavonoids
