摘要
应用国产乳果糖氢呼气试验测定34例正常人及30例甲状腺机能亢进症(甲亢)无腹泻组和36例甲亢伴腹泻组患者的小肠传递时间(SBTT),同步监测血清T_3、T_4.正常组SBTT均值为82.8±26.2 min.无腹泻组为68.8±20.3 min,腹泻组为30.4±36.9 min,后两组分别与正常组比较均有显著性差异(P<0.05,P<0.001).腹泻组T_3、T_4与SBTT均呈显著负相关(r=-0.8973,P<0.001;r=-0.9512,P<0.001).腹泻组经抗甲状腺药物治疗后,T_3、T_4恢复正常时,SBTT亦随之延长(79.4±28.9 min,P<0.001).结果表明:过高的T_3、T_4可使SBTT明显缩短,小肠蠕动加速.SBTT缩短是甲亢患者出现腹泻的主要机理之一.甲亢出现腹泻治疗的根本措施是控制甲状腺功能,其中抗甲状腺药物治疗为其主要手段之一.本研究结果将对甲亢的诊断和治疗提供重要参考价值.
Lactulose hydrogen breath test was evaluated in 34 healthy persons. 30 patients with hypenhyroidism but without diarrhea and 36 cases with hyperthyroidism and diarrhea to investigate small bowel transit time (SBTT) . In the meantime, serium T3, T4 were momitored. The average SBTT values were respectively 82.8±26.2 min in the non-diarrhea group, 30.4±36.9 min in the diarrhea group. The two groups have been compared with heaithy group and to have showed a significant difference (P<0.05, P< 0.01). The dirrhetic T3, T4 and SBTT have revealed a notable negative correlation (r= -0.8973, P<0.001; r=-0.9512, P<0.0001). When T3, T4 are recovery after the antithyoid medicinal treatment. SBTT can prolong to 79. 4±28. 9 min (P < 0.001). The results showed that value T3,T4 may obviously cause short SBTT and fast institinal peristalsis, these can be regarded as a major mechanism of diarrhea in the patients with hyper-throidism. Cardinal measures for hyperthroidism diarrhea treatment should be thytold function control, antithyroid medicinal therapy is one of the methods. The research result would be as an important reference for the diagnosis and treatment of hyperthyroidism.
出处
《临床消化病杂志》
1998年第1期13-15,共3页
Chinese Journal of Clinical Gastroenterology
基金
本课题为烟台市科委基金资助项目
关键词
甲亢
呼气试验
小肠传递时间
病理
Hyperthyroidism Breath test Small bowel transit time
