摘要
目的研究牛磺酸对大鼠实验性高脂血症的影响。方法预先给予β－丙氨酸造成牛磺酸缺乏。建立正常与牛磺酸缺乏大鼠高脂血症动物模型。观察外源性补充牛磺酸对高脂血症大鼠血中总胆固醇（ＴＣ）、甘油三酯（ＴＧ）、低密度脂蛋白胆固醇（ＬＤＬＣ）、高密度脂蛋白胆固醇（ＨＤＬＣ）的影响。结果（１）饲养法可诱发大鼠的实验性高脂血症，体内缺乏牛磺酸时，可加重高脂血症并出现明显动脉粥样硬化的病理改变；（２）每日口服牛磺酸（２ｇ／ｋｇ）能预防大鼠血中ＴＣ、ＴＧ升高或降低大鼠血中ＴＣ和ＴＧ水平，并能降低ＬＤＬＣ水平、升高ＨＤＬＣ水平。结论（１）内源性牛磺酸不足易导致血脂异常升高和动脉粥样硬化性病变；（２）牛磺酸对实验性高脂血症有良好降脂作用。
Aim To study the antihyperlipidemic effect of taurine(Tau) in normal and Tau deficiency rats. Methods β alanine was administrated in rats to induce the endogenous deficiency of Tau. The experimental hyperlipidemia(HL) was established by feeding high cholesterol food for 30 days. The levels of total cholesterol(TC), triglycerides(TG), LDL C and HDL C were examined before and after the administration of Tau. Results (1)The feeding of high lipid food produced HL in rats. Endogenous lack of Tau aggravated the degree of HL in rats; the atherosclerosis(AS) changes were found in these rats additionally. (2)Tau(2 g/kg,day,p.o) prevents the HL induced by feeding cholesterol food,decreases the levels of TC, TG, LDL C, respectively, and increases HDLs. Conclusion (1)Endogenous deficiency of Tau facilitates the development and formation of HL and AS; (2)Tau is an effective agent for antihyperlipidemia.
出处
《高血压杂志》
CSCD
1998年第1期14-16,共3页
Chinese Journal of Hypertension
