摘要
以氯化血红素为起始原料设计合成了６个全新的卟啉衍生物．在Ｄ２Ｏ中对ＮＡＤＰＨ光氧化作用的敏化效应实验表明，所合成的目标化合物均具有光敏活性，其中３，８位含甲氧基、乙氧基、正丙氧基、异丙氧基的卟啉化合物活性明显高于参比药物ＨｐＤ，可望替代ＨｐＤ用于肿瘤的光动力治疗，值得进一步深入研究．
Six new porphyrin derivatives were synthesized from hemin.All of these compounds possessed the sensitivity to photooxidation of NADPH in D 2O. The porphyrins with methoxy,ethyloxy,npropyloxy,isopropyloxyfunctional groups in 3,8position of porphyrin ring had higher sensitivity than HpD,so they are worth further investigation as ideal antitumor drugs used in photodynamic therapy.
出处
《中国药物化学杂志》
CAS
CSCD
1998年第1期1-4,共4页
Chinese Journal of Medicinal Chemistry
