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促性腺激素释放激素类似物在儿童中枢性性早熟中的应用 被引量：4

Application of Gonadotropin-Releasing Hormone Analogue in Treatment of Central Precocious Puberty in Children
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摘要 中枢性性早熟(CPP)是常见的儿科内分泌疾病,其危害是成年身高减损、性征提前出现及心理问题。3～4周缓释型促性腺激素释放激素类似物(GnRHa)是目前国际上公认的治疗CPP的药物。快速进展型CPP是GnRHa的应用指征。近30 a的应用经验证明,GnRHa能有效抑制骨龄进展,在使线性生长减慢的同时,可有效改善成年身高,不良反应少,对成年后生殖轴功能、骨健康及身体成分等无明显负性影响。
作者 马华梅
机构地区 中山大学附属第一医院儿科
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2009年第8期566-568,共3页 Journal of Applied Clinical Pediatrics
关键词 性早熟 中枢性 促性腺激素释放激素 身高 儿童
分类号 R725.8 [医药卫生—儿科]
  • 相关文献

参考文献23

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二级参考文献39

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共引文献78

同被引文献61

  • 1顾学范,韩连书,高晓岚,杨艳玲,叶军,邱文娟.串联质谱技术在遗传性代谢病高危儿童筛查中的初步应用[J].中华儿科杂志,2004,42(6):401-404. 被引量：144
  • 2杜敏联.中枢性(真性)性早熟诊治指南[J].中华儿科杂志,2007,45(6):426-427. 被引量：302
  • 3Roth CL,Brendel L, Ruckert C,et al. Antagonistic and agonistic GnRH analogue treatment of precocious puberty:Tracking gonadotropin concen- trations in urine[ J ]. Horm Res ,2005,63 ( 5 ) :257 - 262.
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  • 8Tung Y C,Lee J S,Tsai W Y,et al. The effects ofgonadotropin re- leasing hormone analogue therapy on gifts with gonadotropin-de- pendent precocious puberty [ J ]. J Formos Med Assoe, 2007,106 (10) :826-831.
  • 9Klein K O, Baron J, Barnes K M ,et al. Use of an uhrasensitive re- combinant cell bioassay to determine estrogen levels in girls with precocious puberty treated with a luteinizing hormone-releasing hormone agonist [ J ]. J Clin Endocrinol Metab , 1998,83 (7) :2387- 2389.
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引证文献4

二级引证文献26

实用儿科临床杂志
2009年 第8期

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