期刊文献+

促性腺激素释放激素类似物治疗儿童特发性中枢性性早熟临床观察 被引量:9

原文传递
导出
摘要 目的观察促性腺激素释放激素类似物(GnRH-a)治疗儿童特发性中枢性性早熟的临床疗效。方法对10例特发性中枢性性早熟儿童给予GnRH-a 100μg/kg,每28d应用1次,治疗6~12个月,观察治疗前后患儿第二性征、性激素水平、身高、骨龄及预测成年身高变化。结果所有患儿第二性征发育减退,性激素水平降低,BA/CA下降,预测成年身高由治疗前的(155±5)cm转为治疗后的(159±6)cm(P〈0.01)。结论GnRH-a可明显抑制第二性征发育,延缓骨龄成熟,有效改善终身高。
作者 朱蓓
出处 《临床医学》 CAS 2006年第8期49-50,共2页 Clinical Medicine
  • 相关文献

参考文献5

二级参考文献44

  • 1蔡德培,季志英,陈伯英,张炜.Pathogenetic Regulation of Female Precocious Puberty and the Mechanism of Therapy with Traditional Chinese Medicine[J].Chinese Journal of Integrative Medicine,2001,7(2):132-134. 被引量:7
  • 2[1]Rogol A,Blizzard RM.Variations and disorders of pubertaldevelopment.In∶ Kappy MS,Blizzard RM,Migeon CJ,eds. Wilkins' the diagnosis and treatment of endo- crine disorders in childhood and adolescence.Springfield,IL∶ Charles C.Thomas,1994∶ 857- 917.
  • 3[2]Marshall WA,Tanner JM.Variations in the pattern of pubertal changes in girls.Arch Dis Child,1969,44∶ 291- 303.
  • 4[3]Marshall WA,Tanner JM.Variations in the pattern of pubertal changes in boys.Arch Dis Child,1970,45∶ 13- 23.
  • 5[4]Herman-Giddens ME, Slora EJ, Wasserman RC, et al. Secondary sexual characteristics and menses in young girls in office practice∶ A study from the pediatric research in office settings network.Pediatrics,1997,99∶ 505- 512.
  • 6[5]Kaplowitz PB,Oberfield SE,and the Drug and Terapeutics and Executive Committees of the Lawson Wilkins Pediatric Endocrine Society.Reexamination of the age limit for defining when puberty is precocious in girls in the United States∶ Implications for evaluation and treat- ment.Pediatrics,1999,104∶ 936- 941.
  • 7[6]Palmert MR,Malin HV,Boepple PA.Unsustained or slowly progressive puberty in young girls∶ Initial presentation and long-term follow-up of 20 untreated patients.J Clin Endocrinol Metab,1999,84∶ 415- 423.
  • 8[7]Klein KO.Precocious puberty∶ Who has it?Who should be treated ? J Clin Endocrinol Metab, 1999, 84∶ 411- 414.
  • 9[8]Lee PA. Central precocious puberty. An overview of diagnosis,treatment,and outcome.Endocrinol Metab Clin North Am,1999,28∶ 901- 918.
  • 10[9]Lebrethon MC,Bourguignon JP.Central and peripheral isosexual precocious puberty.Current Opin Endocrinolo Diabet,2001,8∶ 17- 22.

共引文献57

同被引文献50

引证文献9

二级引证文献43

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部