摘要
新喋呤（Neopterin）是由激活的T细胞产生的γ－干扰素诱导单核巨噬细胞释放的一种嘧啶类物质，是细胞免疫激活的一个标志物，与感染程度密切相关。本文对16例慢性肺心病合并急性呼吸道感染者治疗前后进行外周血新喋呤测定比较，结果显示肺心病急性加重期新喋呤水平明显升高（P＜0．01），对合并呼衰组与未合并呼衰组两者比较，新喋呤在呼衰组明显升高（P＜0．05），揭示新喋呤测定可作为临床感染存在的一个敏感指标。
Neopterin is a pyrimidine compound derived from GTP. It is produced by human macrophages specially stimulated with gammainterferon derived from activation of T cell. In the study, we investigated levels of serum neopterin in sixteen chronic cor pulmonale with acute respiratory tract infection and during the convalescent stage.The results demonstrated that neopterin levels in acute respiratory tract infection is markedly higher than that in the convalescent stage (P <0. 01). Neopterin levels in cor pulmonale with respiratory failure is higher than in that without respiratory failure (P <0. 05). The results suggested that Neopterin may be a senstive marker for infection.
出处
《急诊医学》
CSCD
1998年第1期18-19,共2页
