摘要
在微波辐射下,以甲基硝基胍、正丙胺及甲醛为原料合成1-甲基-5-正丙基-2-硝基亚胺基-六氢化-1,3,5-三嗪。对产物进行红外分析和熔点测定。用正交实验方法对反应温度、反应时间及反应物用量等影响因素进行考察。得到合成反应的优化反应条件:n(甲基硝基胍)∶n(正丙胺)∶n(甲醛)=3∶7.5∶9.5,反应温度50℃,反应时间4min。收率达91.2%。
1-Methyl-2-nitroimino-5-n-propyl-1,3,5-triazacyclohexane was synthesized from methyl nitroguanidine, n-propylamine and formaldehyde under microwave irradiation. The products were identified by means of melting point and IR spectra. Based on the results from orthogonal design experiments, optimal conditions were obtained as： reaction temperature 50℃, irradiation time 4 min, the ratio of raw materials n （ methyl nitroguanidine ） ：n （n-propylamine） ：n （formaldehyde） =3：7.5：9.5. The overall yield was 91.2 %.
出处
《精细化工中间体》
CAS
2009年第2期26-27,59,共3页
Fine Chemical Intermediates
基金
济南大学科研基金(XKY0710)
