摘要
胃泌酸调节素(OXM)是由小肠L细胞分泌的一种肽类激素,它能够透过血脑屏障到达下丘脑弓状核,与其特异性受体结合后发出饱感信号终止动物进食。胃泌酸调节素对动物食欲的调节和内环境稳态的稳定,是通过抑制胃酸分泌、降低采食量、增加能量消耗及动员脂肪分解等生物学功能实现的。论文综述了近年来国内外学者对胃泌酸调节素在来源及结构、生物学功能和作用机理3个方面的研究成果,并阐述了对其进行进一步研究的发展方向。
Oxyntomodulin （OXM）, a peptide hormone,which is released from small intestine L-cell,can go through blood-brain barrier and get to hypothalamic arcuate nucleus, bind with specific receptor, then become a satiety signals to terminate feed intake on animal. Oxyntomodulin plays its role in animal＇s appetite regulation and homeostasis by inhibiting gastric acid secretion, restraining feed intake, enhancing energy expenditure and mobilizing lipolysis. The research results from domestic and foreign scholars in recent years on the source and structure, biological function and mechanism of oxyntomodulin were discussed in this review, and the further research directions were also described.
出处
《动物医学进展》
CSCD
北大核心
2009年第4期87-89,共3页
Progress In Veterinary Medicine
