摘要
目的探讨抗环瓜氨酸肽抗体（抗-CCP）和类风湿因子IgG—Rf联合检测对类风湿关节炎（RA）的诊断价值。方法抗-CCP采用ELISA法定量检测，IgG—Rf采用速率散射免疫比浊法检测。结果68例RA患者抗-CCP、IgG—Rf的灵敏度分别为57．4％和69．1％，61例非RA患者抗-CCP、IgG—Rf的特异度分别为97．6％和89．7％，两者联合检测灵敏度和特异度为30．9％和100％，21例IgG—Rf阴性中有6例抗-CCP阳性，阳性率为28．6％，47例IgG—Rf阳性中有42例抗-CCP阳性，阳性率为89．4％。结论抗-CCP抗体能提高RA的早期诊断率，两者联合检测在RA诊断中可降低RA误诊率，同时提高RA诊断的特异性和阳性预测值。
Objective To explore the clinical value of the combined detection of anti - cyclic citrullinated peptide（anti-CCP） antibody and rheumatoid factor （R f） in the diagnosis of rheumatoid arthritis （RA）. Methods Anti-CCP antibody was measured by ELISA and IgG- Rf were detected by rate nephelometry. Results In 68 patients with RA the sensitivity for anti - CCP antibody and IgG - Rf were 57.4% and 69.1% respectively. In 61 non - RA patients the speciality for anti - CCP was 97. 6% ,and for IgG - Rf was 89.7%. If combined the detection of anti - CCP antibody and IgG - Rf,the sensitivity reached 30.9% ,the speciality reached 100%. In 21 patients with negative IgG - Rf 6 cases were anti - CCP antibody positive, the positive rate was 28.6%. In 47 patients with positive IgG - Rf 42 cases were anti - CCP antibody positive, the positive rate was 89.4%. Conclusions Anti - CCP antibody could improve the accuracy of early diagnosis of RA. The combined detection of anti - CCP antibody and IgG - Rf could reduce the misdiagnosis of RA. Meantime the speciality and the positive predicative value could be raised.
出处
《中国实用医刊》
2009年第9期12-13,共2页
Chinese Journal of Practical Medicine
关键词
抗环瓜氨酸肽抗体
类风湿因子
类风湿性关节炎
Anti -cyclic citrullinated peptide antibody
Rheumatoid factor
Rheumatoid arthritis
