抗CCP抗体与RF联合检测在类风湿性关节炎诊断中的应用价值被引量：9

Clinical value of the combined detection of anti-CCP antibody and RF in the diagnosis of rheumatoid arthritis

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摘要目的:分析评价抗环瓜氨酸肽抗体(抗CCP抗体)定量联合类风湿因子(RF)在类风湿性关节炎(RA)早期诊断中的敏感性及特异性,探讨其对RA的临床诊断价值。方法:取150例RA患者,50例非RA弥漫性结缔组织病,30例正常人血清样本,用ELISA定量检测抗CCP抗体,用Immage特种蛋白分析仪对RF定量检测。采用四格表法计算敏感度及特异性。结果:RA组的RF、抗-CCP抗体敏感度分别为62%、54.7%,特异性分别为51.7%、96.0%。结论:RF敏感性较高,但特异性较差,抗-CCP抗体对RA敏感性较RF差,但具有高度特异性。两者联合检测有助于提高RA的早期诊断率。 Objective：To explore the clinical value of the combined detection of anti-CCP antibody and RF in the diagnosis of rheumatoid arthritis （RA）. nethods：RF was measured by the rate scatting immunity method, Anti-CCP antibody was aleasured by ELISA method in 150 patients with RA and in 50 patients without RA and in 50 normal controls. Results： The sensitivity of RF, anti-CCP antibody were 62%, 54.7% respectively; the speciality of RF, anti-CCP antibody were 51.7%, 96.0% respectively in RA patients. Conclusion ： RF has high sensitivity and low speciality in diagnosis of RA, anti-CCP antibody have high speciality. Thus the combined detection of them may help the diagnosis of RA.

作者朱海龙

机构地区广州中医药大学第一附属医院检验科

出处《现代医药卫生》 2006年第11期1593-1594,共2页 Journal of Modern Medicine & Health

关键词类风湿性关节炎类风湿因子 Rheumatoid arthritis Rheumatoid Factor Anti-Cyclic Citrullinated Peptide antibody

分类号 R446 [医药卫生—诊断学]

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