摘要
目的探讨新生儿期高胆红素血症与不随意运动型脑瘫的相关性。方法回顾性研究36例有明显早期黄疸史的不随意运动型脑瘫患儿新生儿期黄疸情况,采用逐一询问调查问卷方式并详细记录患儿新生儿期高胆红素血症的原因、程度、临床特点及治疗情况等。结果36例患儿高胆红素血症的主要原因为,新生儿溶血病12例(33.3%)、早期感染8例(22.2%)、巨大头颅血肿5例(13.9%)、病因不明11例(30.5%)。36例患儿中早产儿4例。血清总胆红素(TSB)>600μmol/L6例(最高值792μmol/L),513～600μmol/L12例,425～512μmol/L14例,<425μmol/L2例(最低值396μmol/L)。2例患儿因未就诊而无法得知TSB值。黄疸明显加重的时间为出生后(156±12.56)h,持续时间为出生后(923±5.62)d。34例患儿被诊治过,但首次治疗时间均超过出生后150h。结论严重的高胆红素血症作为不随意运动型脑瘫的主要危险因素应受到广大医务人员的重视,如何早期、迅速地降低血胆红素的浓度是减少后遗症的关键。
Objective To investigate the relationship between the neonatal period hyperbilirubinemia and dyskinetic cerebral palsy. Methods The data of 36 dyskinetic cerebral palsy children with early neonatal period significant jaundice were analyzed retrospectively. The information of children was obtained through a questionnaire that included the case, severing clinical characteristics and treatment. Results 12 cases （33.33%） were born with hemolytice disease of newborn; 8 cases （22.2%） were born with early onset infection; 5 cases （13.9%） were born with cephalohematome; others were unknown etiologies. 6 cases had serum total bilirubin （TSB） value more than 600 μmol/L （the highest value was 792 μmol/L） ; 12 cases had TSB value ranged from 513μmol/L to 600μmol/L; 14 eases had TSB value ranged from 425μmol/L to 512μmol/L; 2 cases had TSB value lower than 425μmol/L （the lowest value was 396μmol/L）. 2 cases had no TSB data. The time of jaundice significantly turned severer was 156 ±12.56 hours after birth. The time of jaundice continued was 23±5.62 days after birth. 34 cases had been diagnosed and treated. But the first treatment time of all were later 150 hours after birth. Conclusion As the main risk factor of dyskinetic cerebral palsy, severe hyperbilirubinemia need be valued. How to ease bilirubin quickly in the early stage is much important.
出处
《中国康复理论与实践》
CSCD
2009年第4期366-367,共2页
Chinese Journal of Rehabilitation Theory and Practice
