摘要
目的分析我院铜绿假单孢菌耐药水平与抗菌药物用量的相关性,为临床合理应用抗菌药物提供科学依据。方法采用回顾性调查方法,统计我院2004年1月～2007年12月住院患者6种抗菌药物使用情况以及铜绿假单孢菌的药敏试验结果,统计数据用SPSS13.0统计软件进行多元性回归。结果铜绿假单孢菌对阿米卡星耐药率与亚胺培南用量有线性依存关系;铜绿假单孢菌对氨曲南耐药率与亚胺培南用量有线性依存关系;铜绿假单孢菌对环丙沙星耐药率与妥布霉素用量有线性依存关系。结论耐药性铜绿假单孢菌的增多与抗菌药物的消耗量之间存在一定的量化关系,临床应尽可能根据药敏试验结果合理使用抗菌药物,限制滥用抗菌药物,减少耐药产生。
Objective To comprehend the quantitative relationship between the levd of pseudomonas aeruginoss resistance and dosage of antibiotices for providing the scientific foundation of the rational antibiotic therapy. Methods A retrospective study was conducted to statistic the dosage of 6 kinds of antibiotic of in-patient departent and pseudomonas peruginosa aureus sensitivity-test result of the affiliated hospital of Luzhou medical collage from January 2004 to December 2007.The statistical datas was processed by SPSS 10.0 software for multiple liear regression. Results The consumpation amount of imipenem was related to the resistance of pseudomonas aeruginosa aureus to amikacin. The consumpation amount of imipenem was correlated to the resistance of pseudomonas aerugincea auretts to aztreonam. The consumpation amount of tobramycin was correlated to the resistance of pseudomonas aeruginosa aureus to ciprofloxacin. Conclusion There is certain quantitative relationship between drug resistance of pseudomonas aeruginosa and the consumption of antibiotics. Antibiotics should he used rationally in accordance with clinical sensitivity test results as far as possible, to limit the abuse d antibiotics and reduce drug resistance.
出处
《四川医学》
CAS
2009年第4期592-594,共3页
Sichuan Medical Journal
关键词
铜绿假单孢菌
耐药水平
消耗量
相关性
pseudomonas acruginosa
drug-resistanse
dosage
relationship
