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基因分型对乳腺癌诊治和预后判断的指导作用 被引量：1

Clinical values of genotyping in diagnosis,treatment,and prognosis of breast cancer
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摘要 乳腺癌是女性的常见恶性肿瘤之一,其临床治疗主要是以经典的TNM和临床分期为指导。近年来兴起的对乳腺癌相关的分子遗传学研究取得了令人瞩目的进展,提出了乳腺癌基因分型这一新概念。基因诊断对乳腺癌的辅助化疗以及预后的判断相对传统的病理分型有更高的专一性,为乳腺癌的治疗起到了更好的指导作用,本文主要对基因分型进行介绍并总结了几种与乳腺癌预后相关的基因标志,探讨其在临床治疗中的实际应用。 Breast cancer is a common malignant tumor in women. The treatment is mainly guided by the TNM and clinical staging. Molecular genetics of breast cancer has made a significant progress in recent years and the genotyping of breast cancer has been introduced as a new concept. Compare to the traditional pathological typing, the genetic diagnosis can provide more specific information to adjunctive therapy and prognosis of breast cancer. This article summarizes the clinical application of this technology.
作者 胡欣 王昆华 包维民
机构地区 昆明医学院附属云南省第一人民医院普外一科
出处 《癌症进展》 2009年第2期141-145,共5页 Oncology Progress
关键词 乳腺癌 基因分型 预后 breast cancer genotyping prognosis
分类号 R737.9 [医药卫生—肿瘤]
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参考文献10

  • 1Benjamin HK,,Christine D,Fanny P,et al.Comparison of prognostic gene expression signatures for breast cancer[].BMC Genetics.2008
  • 2Stella Mook,Marjanka KS,Giuseppe V,et al.The 70 -gene prognosis-signature predicts disease outcome in breast cancer patients with 1-3 positive lymph nodes in an independent validation study[].Breast Cancer Research.2008
  • 3Perou C M,Sorlie T,Eisen M B,et al.Molecular portraits of human breast tumours[].Nature.2000
  • 4Balint E E,Vousden K H.Activation and activities of the p53 tumor suppressor protein[].British Journal of Cancer.2001
  • 5van ’t Veer LJ,Dai H,van de Vijver MJ,et al.Gene expression profiling predicts clinical outcome of breast cancer[].Nature.2002
  • 6Balint E E,Vousden K H.Activation and activities of the p53 tumor suppressor protein[].British Journal of Cancer.2001
  • 7Desmedt C,Piette F,Loi S,et al.Strong timedependence of the76-gene prognostic signature fornode-negative breast cancer patients in the TRANSBIGmulticenter independent validation series[].Clinical Cancer Research.2007
  • 8Hu Z,Fan C,Oh DS,et al.The molecular portraits of breast tumors are conserved across microarray platforms[].BMC Genetics.2006
  • 9Calza S,Hall P,Auer G,et al.Intrinsic molecular signature of breast cancer in a population-based cohort of412patients[].Breast Cancer Research.2006
  • 10Whitfield,M.L.,Sherlock,G.,Saldanha,A.J.,Murray,J.I.,Ball,C.A.,Alexander,K.E.Identification of genes periodically expressed in the human cell cycle and their expression in tumors[].Molecular Biology of the Cell.2002

同被引文献17

  • 1Goldhirsch A, Wood WC, Coates AS, et al. Strategies for subtypes dealing with the diversity of breast Cancer: high- lights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011[J]. Ann On- col, 2011, 22(8),1736-1747.
  • 2Hammond ME, Hayes DF, Wolff AC, et al. American society of clinical oncology/college of American pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer[J]. J Clin Oncol, 2010, 6(4) :195-197.
  • 3程虹,戴林,郭双平,等.乳腺及女性生殖器官肿瘤病理学和遗传学[M].北京:人民卫生出版社,2003:16-18.
  • 4Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumors[J]. Nature, 2000, 406 :747-752.
  • 5O'brien KM, Cole SR, Tse CK, et al. Intrinsic breast tumor subtypes, race, and long-term survival in the carolina breast cancer study[J]. Clin Cancer Res, 2010, 16(24) :6100-6110.
  • 6Chuthapisith S, Permsapaya W, Warnnissorn M, et al. Breast cancer subtypes identified by the ER, PR and HER-2 status in Thai women[J]. Asian Pac J Cancer Prev, 2012, 13 (2) : 459- 462.
  • 7Telli ML, Chang ET, Kurian AW, et al. Asian ethnicity and breast cancer subtypes: a study from the California cancer reg- istry[J]. Breast Cancer Res Treat, 2011, 127(2):471-478.
  • 8Leong SP, Shen ZZ, Liu TJ, et al. Is breast cancer the same disease in asian and western countries? [J].World J Surg, 2010, 34(10) :2308-2324.
  • 9Anders CK, Hsu DS, Broadwater G, et al. Young age at di- agnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression[J]. J Clin Oncol, 2008, 26(20):3324-3330.
  • 10陶苹,胡耀月,黄源,等.亚裔女性乳腺癌危险因素的Meta分析[J].中华流行学杂志,2011,32(2):164-168.

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癌症进展
2009年 第2期

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