摘要
目的探讨Kimura病的临床病理特征和诊断。方法对7例Kimura病进行临床资料分析、光镜观察和免疫组织化学检测,并结合文献对其鉴别诊断进行讨论。结果该病好发于男性,临床上表现为头颈部或肘部无痛性软组织肿块,形态学上以淋巴滤泡增生伴生发中心扩大、嗜酸性粒细胞浸润、小血管增生和间质纤维化为基本病变,免疫组化染色κ和λ的共同表达提示KD是一多克隆增生性疾病。结论Kimura病是一种病因不明的特异性炎症病变,应与上皮样血管瘤相鉴别。
Objective To investigate the clinical pathology and diagnosis of Kimura＇s disease（KD）. Methods Seven cases of KD were analyzed with clinical data, light microscopy and immunohistochemistry, meanwhile the different diagnosis were discussed referring literature. Results KD were occurred predominantly in males, and presented clinically as painless soft tissue masses in the head, neck and elbow regions. Its fundamental pathological changes were lymph foilicie hyperplasia accompanying with enlargement of Fleming＇s center, marked eosinophils infiltration, small vascular proliferation and interstitial fibrosis, and the co-expression of immunohistochemistry staining of κ and λ. All these indicated that KD is a disease of multiclonal acerementition. Conclusion KD is a agnogenic and specially inflamed process, and should be discriminated from Epithelioid Hemangioma.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2009年第4期319-321,共3页
Cancer Research on Prevention and Treatment
