摘要
目的探讨联苯苄唑曲安奈德乳膏治疗体股癣的有效性和安全性。方法将110例体股癣患者随机分为观察组和对照组,各55例。观察组采用联苯苄唑曲安奈德乳膏进行治疗,而对照组采用1%联苯苄唑乳膏治疗。对两组在用药1wk、用药2wk及停药2wk时的真菌学疗效、临床疗效、临床症状和体征改善情况和用药过程中不良反应进行评估,并进行对比性分析。结果两组在用药1wk、用药2wk、停药2wk各时点的真菌学和临床疗效差异无统计学意义,均P>0.05。观察组在用药2wk时的红斑、瘙痒、丘疹和角化等症状消失所用时间明显少于对照组,均P<0.01(t=4.109,4.782,3.152,4.836)。两组均未见严重不良反应。结论联苯苄唑曲安奈德乳膏治疗体股癣安全、有效,且比联苯苄唑单一制剂具有更好的抗炎作用。
Objective To investigate the efficacy and safety in the treatment of tinea corporis/cruris. Methods A total of 110 cases of tinea corporis/cruris were randomly assigned to the observation and control group, each consisting of 55 cases. The former was treated with bifonazole and triamcinolone acetonide acetate crem, while the latter treated with 1% bifonazole crem. The fungal, clinical efficacies 1, 2 wk after treatment and 2wk after withdrwal, improvement in clinical signs and symptoms and adverse reactions during treatment were assessed, and the comp＇arative analyses were performed. Results No significant differences in fungal and clinical efficacies at various periods were noted between two groups, all P〉0.05. The disappearing times of erythema, pruritus, papule and cornification were considerably shorter in the observation group than in the control group, all P〈O.O1 （t=4.109,4.782,3.152,4.836 respectively）. No severe side effect was found during therapy. Conclusion Bifonazole and triamcinolone acetonide acetate crem proves to be effective and safe for the treatment of tinea corporis/cruris, and alson possess better anti-inflammatory action than single triamcinolone acetonide acetate crem.
关键词
联苯苄唑
曲安奈德
乳膏
体股癣
Bifonazole
Triamcinolone acetonide acetate
Crem
Tinea corporis/cruris
