摘要
为了探讨微量元素对汞中毒的拮抗作用，用氯化汞制备小鼠汞中毒模型，使其发生明显脂质过氧化损伤，经硒、锌、钼预处理后再给同剂量氯化汞，可降低汞中毒鼠的死亡率，肝、肾、脑组织中脂质过氧化物含量明显降低，超氧化物歧化酶活性相应增高（Ｐ＜０．０１）。提示硒、锌、钼能拮抗汞引起的致死作用和脂质过氧化作用，其拮抗强度依次为钼＞锌＞硒。这为汞中毒防治提供新的途径。
o study the effects of trace elements on mercury intoxicution in mice,mercury poisoning mode was prepared with HgCl2 in mice that induced obvious lipid peroxidation damage.After pretreament with Se、Zn and Mo respectively,the mortalities of mercury poisoned mice were decreased,the contents of the LPO products in livers,kidneys and brains of poisoned mice were reduced,and the activity of SOD was increased(P<001).It is suggested that Se、Zn and Mo might have antagonistic effect against the mortalities and lipid peroxidation caused by mercury.The intensity of antagonism seems Mo>Zn>Se.The results supply a new way in prophylaxis and treatment of mercury poisoning..
出处
《中国工业医学杂志》
CAS
1998年第1期19-21,共3页
Chinese Journal of Industrial Medicine
关键词
汞中毒
微量元素
拮抗
脂质过氧化
Mercury poisoning
Trace element
Antagonistic effect
Lipid peroxidation
