摘要
为探讨硬化药物对人体囊肿的治疗作用机制，评价不同硬化药物的疗效，建立家兔胆囊动物实验模型。７５只家兔分成３组，手术结扎胆囊管，生理盐水冲洗后注入两组硬化药物，１ｄ、３ｄ、７ｄ、１４ｄ、２１ｄ手术切除胆囊取材。结果：组合硬化剂实验组胆囊壁上皮细胞破坏均匀，囊内渗液、出血量少，吸收快，纤维化明显；无水乙醇对照组胆囊壁反应剧烈，上皮细胞破坏不均衡，囊内渗液、出血多，吸收慢，纤维组织增生少；生理盐水空白组胆囊上皮细胞无改变。
To investigate the effect and mechanism of sclerosing drugs on cyst of the human body,we have established a cyst model by using rabbit gallbladder.The main process of making the cyst model consisted of ligating biliary ducts,drawing bile from the ballbladder and washing the ballbladder repeatedly with normal saline until the drawn liquid became clear.Seventyfive rabbits were divided into three groups.Two kinds of sclerosing drugs were injected into the cyst model,namely,cystsimulating gallbladder(CSG).The CSGs were respectively removed 1d,3d,7d,14dand 21d after the operation.The results revealed that(1)in the compound sclerosing drug group,the epithelial cells of the CSG wall suffered from homogeneous lesion,the exudate from the CSG contained less blood ,it was absorbed quickly and there was obvious fibrosis ;(2) in the anhydrous alcohol group,the CSG reacted to sclerosing agent grievously,the lesion of epithelial cells of CSG wall was not homogeneous,much blood was found in exudate from CSG,it was absorbed slowly ,and there was less proliferation of fibrous tissues;(3)in the normal saline group,there were no significant changes in the epithelial cells of CSG wall.
出处
《承德医学院学报》
1998年第1期18-22,共5页
Journal of Chengde Medical University
关键词
肝囊肿
囊肿硬化治疗
动物模型
硬化药物
cyst
sclerotherapy
cyst modelDepartment of Histology and Emoryology,Chengde Medical College
