摘要
目的:研究杜仲籽总苷的抗炎、镇痛作用。方法:采用二甲苯所致小鼠耳肿胀和大鼠角叉菜胶足肿胀方法,研究杜仲籽总苷的抗炎作用;采用热板法、醋酸扭体法、光照甩尾法,研究杜仲籽总苷的镇痛作用。结果:杜仲籽总苷的110、220 mg/kg剂量都能明显减少二甲苯所致小鼠耳肿胀的体积,杜仲籽总苷的55、110、220 mg/kg剂量在给药后4 h左右明显减少大鼠角叉菜胶足肿胀率;杜仲籽总苷的220 mg/kg剂量能显著提高热板和光电引起小鼠的痛阈值,杜仲籽总苷的110、220 mg/kg剂量能显著地减少醋酸引起的扭体次数。结论:杜仲籽总苷具有较强的抗炎、镇痛作用。
Objective： To investigate the anti-inflammatory and analgesic activity of Eucomrniae ulrnoides seed total glycoside（EUG）. Methods： Dimethyl benzene（DB）-induced mouse ear edema model and carrageein-induced rat paw edema model were employed for the anti inflammatory activity experiment. The experiment for analgesic activity was done using hot plate test, photoelectricity-induced test and acetic acid induced writhing method. Results： EUG at 110,220 mg/kg showed an obvious inhibitory effect against DB-induced mouse ear edema volume, and at 55, 110, 220 mg/kg it showed an obvious analgesic effect against carrageein-induced rat paw edema rate 4 hours after oral administration. At 220 mg/kg EUG notably raised the pain threshold in the mice stimulated by hot plate and photoelectricity. At 110,220 mg/kg EUG greatly reduced the number of acid-induced writhing. Conclusion： The result suggests that EUG has potential anti-inflammatory and analgesic activity.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2009年第4期413-415,共3页
Academic Journal of Second Military Medical University
基金
国家科技部支撑计划(2006BAI06A19-09)~~
关键词
杜仲籽总苷
抗炎
镇痛
Eucommiae ulmoides seecl total glycoside
anti-inflammatory
analgesic
