摘要
采用１０周随机双盲平行对照方法，研究舍曲林与氟西汀对抑郁症的治疗情况，对６３例病人采用ＨＡＭＤ、ＨＡＭＡ和ＳＥＣＬ评定。结果发现，两组药物治疗后ＨＡＭＤ评分均较疗前有明显下降，第１０周减分率舍曲林组为８１．８％，氟西汀组为７８．１％，两组副反应均较小，组间无显著差异。作者就抑郁症病人的治疗问题提出讨论。
Objective:To compare the efficacy and side effects of sertraline and fluoxetine in major depression. Method:63 patients with major depression were treated in a double blind controlled study at the different stages of ten weeks. Sertraline was compared with fluoxetine. HAMD, HAMA and SECL were used to analyse the improvement of the patients. Results:Compared with premedication, the reduction of HAMD was significant in both of these two groups at the end of the ten weeks: sertraline reductive ratio was 81 8%, fluoxetine was 78 1%. The side effects were slight, and there was no significant difference between these two groups. Discussion:Sertraline and fluoxetine are both effective antidepressants with few side effects.SSRIs may be drugs of choice in the treatment of depression.
出处
《临床精神医学杂志》
1998年第2期72-73,共2页
Journal of Clinical Psychiatry
