摘要
目的探索性激素与胆囊结石形成的关系方法用大白兔为实验动物，共60只，分成6组，每组10只，其中E2，P，T，H4组分别给予雌二醇，孕酮，睾酮和绒毛膜促性腺激素；C1，C2为对照组，分别给予生理盐水和精茶油.实验时间6wk.完成实验后处死动物，检测血液、胆汁、胆囊、胆管、肝脏及胆石．结果雌二醇组（E2组）90％成石；绒毛膜促性腺激素（H组）组内雌性兔100％成石，雄性兔无结石形成；孕酮组（P组）无结石形成；睾酮组（T组）仅1例形成胆囊结石，对照组（C1，C2组）均无结石形成.成石动物的胆囊结石均为胆固醇性结石.结论雌二醇，绒毛膜促性腺激素与胆囊胆固醇性结石的形成有一定关系．
AIM To Know whether the sex hormones played a role in formation of gallstone, the experimental study on the drugs was designed.METHODS Sixty rabbits were randomly divided into 6groups, in 4 of which (groups E2, P, T, H) estradiol,progesterone, testosterone and HCG were administered seperately, and normal saline and refined oil were given to as control in the other groups (C1, C2). The animals were sacrificed after 6 weeks. The blood, bile,gallbladder, bile duct, liver and gallstones were assayed.RESULTS The gellstone formation rate was 90% in group E2, 50% in group H and 10% in group T. No gallstone was formed in groups P, C1 and C2. Most of the gallstones were found in the female animals, only in group E2 were the gallstones were found in 4 male rabbits. The compostion of stone was mainly cholesterol.CONCLUSION Estradiol and HCG have relation to the formation of gallbladder cholestrol stone.
出处
《世界华人消化杂志》
CAS
1998年第S2期219-220,共2页
World Chinese Journal of Digestology
