摘要
"证候-基因组"研究实施8年来,在取得一系列成绩的同时,也出现许多亟待解决的问题。笔者根据研究心得归纳出样本细化难、采样难、海量数据分析难、中医证与西医病结合难、中医证候理论与基因功能对接难及证候-基因组学应用难6大难题,并提出建立中医证的特征基因数据库、结合已知基因功能阐释证的可能机制,实现中医证候理论现代化;加快未知基因的研究,占领基因功能注释新领地等可能应对的策略。
Syndromes-genome research performed eight years ago, has made a series of achievements. At the same time,there are still many problems which have to be solved. Based on the research experience, six major problems were summed up, such as difficult to refine into a sample, difficult to sample, difficult to analysis mass data, difficult to combine TCM with western medicine disease, difficult to dock and function between TCM theory and genes, difficult to apply the result of Syndrome- genomics. In this paper, the author also put forward possible new strategies, such as establishing the characteristics of the gene database, combining with the known gene functions likely to explain the evidence of the mechanism for the realization of the modernization of TCM theory, speeding up the unknown gene research, occupying gene annotation territories.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2009年第4期405-407,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金海外青年学者合作项目(No.30528029)
河南省医学科技创新人才工程项目(No.2005075)
河南中医学院博士基金资助(No.200808)
关键词
证候-基因组
证
对接
Syndromes-genome
Syndrome
Docking
