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ABCG2与恶性血液病耐药相关性的研究进展 被引量：2

Adavance of Research on Relationship between ABCG2 and Drug Resistance in Hematologic Malignancies——Review
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摘要 ABCG2作为一种跨膜半转运蛋白,参与了内源及外源有害物质的外排,对机体正常组织起到了保护作用,但同时也介导了对多种化疗药物的外排,引起多药耐药,使许多恶性肿瘤患者对化学药物治疗不敏感,直接影响到临床预后。本文将对ABCG2基因的单核苷酸多态性(SNP)、ABCG2与干细胞和酪氨酸激酶抑制剂(TKI)之间的关系的一些研究进展做简要介绍,同时还对ABCG2与恶性血液病耐药相关性的临床研究结果做回顾性分析,从中可以看出目前研究中存在的问题及未来的研究方向。 ABCG2, a half-transporter concerning with the endo and exon-toxin-efflux, plays an important role in protecting the normal tissues from the toxin-hurt as well as mediating the multidrug resistance, because many of the chemotherapeutic drugs are the substrate of ABCG2. In this paper, the advance of research about this genes single nucleotide polymorphisms （SNPs） was explained concisely. The relationship among ABCG2, the stem cells and the tyrosine kinase inhibitor （TKI） was reviewed. The research about drug resistance related-progress in hematologic malignancies was analyzed retrospectively and the present problems and the perspective in the future were discussed.
作者 曲士强 傅铮铮 吴德沛
机构地区 苏州大学附属第一医院、江苏省血液研究所
出处 《中国实验血液学杂志》 CAS CSCD 2009年第2期513-518,共6页 Journal of Experimental Hematology
关键词 ABCG2 多药耐药 恶性血液病 单核苷酸多态性 肿瘤干细胞 酪氨酸激酶抑制剂 ABCG2 multidrng resistance hematologic malignancy single nucleotide polymorphisms cancer stem cell tyrosine kinase inhibitor
分类号 R733 [医药卫生—肿瘤]
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参考文献33

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同被引文献36

  • 1关剑,陈孝平,朱虹,罗顺锋.乙型肝炎病毒X蛋白上调肝癌多药耐药相关基因表达的研究[J].肝胆外科杂志,2004,12(3):214-216. 被引量：6
  • 2关剑,陈孝平,丁磊.乙型肝炎病毒x蛋白与肝癌生物学特性的研究[J].中华实验外科杂志,2004,21(9):1062-1064. 被引量：4
  • 3李高鹏,陈孝平,王其,徐宗全,张万广,叶露.多药耐药相关蛋白在肝癌多药耐药细胞系HePG2／ADM中的作用[J].中华普通外科杂志,2006,21(11):766-768. 被引量：5
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  • 5Robey RW, Shukla S, Finley EM, et al. Inhibition of P-glyco- protein (ABCB1) and multidrug resistance associated proteinl (ABCCI) mediated transport by the orally administered inhibitor, CBT-1 (R). Biochem Pharmacol, 2008; 75(6):1302-1312.
  • 6Marques DS, Sandrini JZ, Boyle RT, et al. Relationships between multidrug resistance (MDR) and stem cell markers in human chronic myeloid leukemia cell lines. Leuk Res, 2010 ; 34 (6) : 757 - 762.
  • 7Ho MM, Hogge DE, Ling V. MDR1 and BCRP1 expression in leukemic progenitors correlates with chemotherapy response in acute myeloid leukemia. Exp Hematol, 2008; 36(4) .. 433 -442.
  • 8Frank NY, Margaryan A, Huang Y, et al. ABCB5-mediated doxo- rubicin transport and chemoresistance in human malignant melanoma. Cancer Res, 2005; 65(10) :4320 -4333.
  • 9Schatton T, Murphy GF, Frank NY, et al. Identification of ceils initiating human melanomas. Nature, 2008 ; 451 (7176 ) :345 - 349.
  • 10Frank NY, Frank MH. ABCB5 gene amplification in human leukemia ceils. Leuk Res, 2009 ; 33 ( 10 ) : 1303 - 1305.

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中国实验血液学杂志
2009年 第2期

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