摘要
目的观察周剂量多西紫杉醇联合顺铂(DDP)、5-氟尿嘧啶(5-Fu)治疗晚期胃癌的临床疗效和毒副作用。方法晚期胃癌患者28例,给予多西紫杉醇35 mg/m^2,静脉滴注1 h,第1、8、15天;DDP 75 mg/m^2,均分第1～3天静脉滴注,5-Fu 500 mg/m^2,24 h中心静脉置泵持续滴注,第1～5天,28d为1个周期。化疗2～6个周期后按WHO实体瘤疗效评价标准(RECIST)评定疗效,按WHO标准评价不良反应。结果全组28例均可评价疗效,其中完全缓解(CR)2例,部分缓解(PR)13例,稳定(SD)7例,近期客观有效率53.4%,中位疾病进展时间(TIP)为8.7个月,中位生存期(MS)为11.8个月,1年生存率为47.8%。主要不良反应为骨髓抑制和胃肠道反应。但Ⅲ～Ⅳ度发生率较低。结论周剂量多西紫杉醇联合DDP和5-Fu治疗晚期胃癌疗效较好,患者毒副作用轻,耐受性好,值得进一步推广使用。
Objective To investigate the clinical value and toxicity of weekly docetaxel combined with cisplatin / 5-fluorouracil chemotherapy for patients with advanced gastric cancer(AGC).Methods Twenty eight patients with advanced gastric cancer(AGC)were treated with weekly docetaxel 35mg/m2 iv infu- sion for 1 hour in the first,eighth,and fifteenth days combined with DDP 75 mg/m^2 iv infusion in three days and 5-Fu 500 mg/m^2 continuous intravenous infusion for 24 h from the first to the fifth day,and repeat the regimen every 28 days.The efficacy and toxicity was evaluated after 2～6 cycles.Results Twenty eight pa- tients were evaluated for clinical response:CR 2 cases,PR 13 cases,SD 7 cases.The clinical beneficial re- sponse rate was 53.4 %.Median time to progression(TIP)was 8.7 months and median survival time was 11.8 months,the overall 1-year survival rate was 47.8 %.The main side effects were bone marrow suppression and nausea.Conclusion Chemotherapy of weekly docetaxel combined with cisplatin/5-fluorouracil is an effec- tive and well tolerated regimen in the treatment of AGC.
出处
《肿瘤研究与临床》
CAS
2007年第4期241-242,246,共3页
Cancer Research and Clinic
关键词
胃肿瘤
抗肿瘤联合化疗方案
多西紫杉醇
Gastric neoplasms
Antineoplastic combined chemotherapy protoeols
Docetaxel
