摘要
应用OKT单抗对20例初诊晚期宫颈癌和15例慢性淋巴性甲状腺炎(CLT)患者的外周血T淋巴细胞亚群检测结果表明,与正常人相比,宫颈癌患者OKT_3和OKT_4细胞均明显减少,OKT_8细胞明显增多,OKT_4/OKT_8比值显著降低,CLT患者OKT_3和OKT_8细胞减少,OKT_4/OKT_8比值显著升高。本研究表明宫颈癌和CLT均有T细胞亚群的紊乱,提示OKT_4/OKT_8比值的相对平衡是决定机体免疫状态和免疫反应水平的中心环节。
Peripheral blood T lymphocyte subset in 20 cases of patients with advanced cervical cancer and 15 cases of patients with chronic lymphocytic thyroiditis(CLT) were studied by the use of the indireet fluorescent technic with OKT monoclonal antibodies. The results showed that comparing with normal controls, the total T cells and helper T cell (T_H cell)in patients with cervical cancer were much lower (P<0.001).So the T_H/T_3 cell ratio decreased significantly (P<0.001). In patients with CLT however, the total T cell was lower(P<0.001).And the T_H/T_3 cell ratio increased significantly (P<0.001). Our findings indicated that three was disorder of T lymphocyte subsets in both of cervical cancer and CLT,and these disorders represented completely opposite immunologic abnormalities. The immune system in pateints with cancer was sup pressed and in patients with CLT it was relatively active. Our studies suggested that maintenance of a state of relative equilibrium of Tr_H/T_3cell ratio is essential to body immune meechanism, and body immune rcsponsc.
关键词
宫颈癌
T细胞亚群
单克隆抗体
cervical cancer
chronic lymphocytic thyroiditis
T lymphocyte subsets
OKT monoclonal antibodies
