摘要
应用 OKT 单克隆抗体检测了76例自身免疫性甲状腺疾病患者外周血 T 淋巴细胞亚群。结果表明 GD 与 HT 患者总 T 细胞分别为66.55±5.5%和67.0±4.9%,T_s 细胞分别为20.8±5.3%和17.9±2.2%,与正常对照组(70.0±4.4%,26.8±2.1%)相比均减少,而 GD 与 HT 患者的T_H/T_s 细胞比值明显增高(P<0.01)。本研究发现临床缓解的 GD 患者按其 T_H/T_s 值的高低,可进一步分为二种不同的细胞免疫病理类型,即细胞免疫正常型与细胞免疫异常型。GD 患者血清 T_3,T_4值与 T_H/T_s 值之间存在有正相关关系,本研究证明本病存在有 T 细胞亚群平衡的紊乱。
T Iymphocyte subsets in 60 case of patients with Graves'disease(GD),16 cases of patients with Hashimoto's thyroiditis(HT)and 35 of normal controls were examined with OKT monoclonat anti- bodies.The results showed that total T cell and suppressor T cell (T_s)in GD and HT were significantly lower (20.8±5.3% and 17.9×2.2% respectively and helper T cell (T_H)/T_s cell ratio was much higher(2.35±0.46 and 2.62±0.29 respectively)than those in controls (26.8±2.1%,1.79±0. 14).The group of patients whose serum T_3,T_4 had recovered to normal could be further divided into subgrouupseither of higher T_H cell/T_s cell ratio(>2.07)or normal(≤2.07),So two different immunopathologic ypes were showed in the patients with GD as if normal cellular immunith type and the other abnormal cellular immunity type.The patients with GD being liable to relapse perhaps belong to the latter.A possitive correlation between the serum T_3,T_4 and the ratio of T_H cell/T_s cell was found in patients with GD.Our findings suggest that patients with GD and HT have the disturbance of im- munoregulation.
基金
福建省卫生厅青年科学基金部分资助课题
