摘要
目的为探讨体外超声波溶解血栓效应的最佳强度。方法取健康人全血标本１６３份，３７℃恒温形成体外血栓，分组暴露血栓于８００ｋＨｚ的１．２Ｗ／ｃｍ２、１．８Ｗ／ｃｍ２和２．７Ｗ／ｃｍ２脉冲式超声波。计算血栓溶解率，血栓溶解液沉渣作光镜下血栓碎片监测。结果超声波具有明显的溶栓作用，三组超声强度的血栓溶解率分别为１４．２２±３．５５％、２１．２３±３．９４％和３６．７０±６．８８％，随超声波强度加大，溶栓效应增强，二者间存在显著正相关（ｒ＝０．７７８，ｎ＝１０９）。镜检血栓溶解液颗粒均小于２０μｍ。结论在一定条件下，超声波为一安全有效的溶栓措施，具有潜在的临床实用价值。
Objective It aimed to assess the relationship between ultrasonic energy and ultrasoundinduced thrombolysis and to select the best ultrasonic energy for thrombolysis.Methods 163 thrombi were formed in 37℃ by whole blood samples from the healthy volunteers.The thrombi,divided into different groups,were exposed to pulsed ultrasound of 800 kHz at 1.2,1.8,and 2.7 W/cm2.The rates of thrombi lysis were calculated and the samples of the thrombus solution were observed under a hight microscope for analysing particulate size.Results The thrombi lysis rates in three groups exposed to different ultrasonic energys were 14.22±3.55%,21.23±3.94% and 36.70±6.88% respectively.Ultrasoundinduced thrombolysis had a closely relationship with ultrasonic energy.With increase of ultrasonic power output,the lysis rate went higher and higher(r=0.778,n=109).The particulate sizes in the thrombus solution were under 20 μm in diameter.Conclusion Ultrasound has the potential to be one of the effective and safe methods for thrombolysis and could be used clinically in the near future.
出处
《中华物理医学杂志》
CAS
CSCD
1998年第1期17-18,共2页
Chinese Journal of Physical Medicine and Rehabilitation
关键词
血栓形成
超声波疗法
thrombosis/ther
ultrasonic therapy
