摘要
目的观察葛根素对大鼠肝脏缺血再灌注损伤防护作用的剂量效应和时间效应。方法雄性SD大鼠,建立肝脏缺血再灌注模型(HIR)。随机分为假手术组、HIR组和HIR-葛根素预处理组。给予不同剂量的葛根素预处理一段时间后,观察葛根素保护肝脏缺血再灌注损伤的剂量效应和时间效应。结果肝脏缺血再灌注后,模型组动物每天给予口服灌胃不同剂量的葛根素,连续7d后,肝脏组织中MPO活性逐渐升高。同40mg/kg剂量组相比,当葛根素剂量>40mg/kg时,肝脏组织中MPO活性变化不明显;同时,各组动物每天口服灌胃40mg/kg的葛根素后,随着给药时间的延长,肝脏组织中MPO活性逐渐升高。结论葛根素对大鼠肝脏缺血再灌注损伤的预处理保护效应具有一定的时间和剂量依赖性。
Objective To investigate the protective effect and its role of kakkonein on hepatic ischemia reperfusion injury in rats. Methods Male Sprague-Dawley rats were randomly divided into three groups：pseudo-operation normal control group,hepatic ischemia reperfusion injury model group,kakkonein group.After hepatic ischemia and reperfusion,to analysis the effects of time and dose after treated with kakkonein.Results Comparing to the hepatic ischemia reperfusion injury model group,the MPO activity increased.Conclusion The kakkonein have a prominent protective effect with dose and time effect on hepatic ischemia reperfusion injury in rats.
出处
《中外医疗》
2009年第4期78-79,共2页
China & Foreign Medical Treatment
关键词
葛根素
缺血再灌注
肝脏
Kakkonein
Ischemia reperfusion
Liver
