摘要
为探讨阿霉素肾病的发病机理，本文研究了阿霉素肾病（ＡＮ）大鼠肾小球内源性抗氧化酶（ＡＯＥ）活性及其与肾小球损害的关系，发现ＡＮ大鼠肾小球内源性ＡＯＥ活性明显低于正常大鼠（Ｐ＜０．０１），而肾小球脂质过氧化水平明显高于正常大鼠。作者认为。
n order to investigate the pathogenesis of adriamycin-induced nephropathy(AN), endogeneous glomerular antioxidant enzymes(AOE) in AN rats and their relation to glomerular injury were studied. It was demonstrated that glomerular AOE activities are signficantly suppressed and the level of glomerular lipid peroxidation is significantly higher in AN rats than in normal group(P<001). Our data suggest that one of the mechanisms of AN may be channeled through the increased production of reactive oxygen species (ROS) and/or inactivation of endogeneous AOE.
出处
《实验动物科学与管理》
1998年第1期1-3,共3页
Laboratory Animal Science & Administration
关键词
阿霉素
肾病
抗氧化酶
活性氧簇
Adriamycin-induced nephropathy
antioxidant enzyme
reactive
oxygen species
lipid peroxidation
