摘要
目的 研究长期服用雷公藤对系统性红斑狼疮患者骨骼系统的远期影响。方法 采用灵敏度高的双能 X线骨矿物质密度测定仪对 71例系统性红斑狼疮患者及其按年龄、性别、体重、身高相配对的健康对照者进行腰椎骨矿物质密度测定。结果 长期服用雷公藤组患者腰椎骨密度显著下降 ,其骨密度下降程度与累计服药时间有关。结论 长期服用雷公藤对系统性红斑狼疮患者骨骼系统有显著影响 ,使之以后发生骨质疏松和骨折的危险度增加 ,应引起临床医师的重视。
Objective To investigate the effect on skeletal system in SL E patients after long-term administration of Tripterygium Wilfordii( TW) . Methods The bone mineral density( BMD) of lumbar vertebrae 2～ 4 was detected by dual energy X-ray absorptiometry( DXA) with high sensitivity in 71SL E patients and healthy controls matched with age,sex,weight and height.Results ( 1) L ong-term adminis- tration of TW could significantly decrease BMD level. ( 2 ) The degree of this effectwas significantly associ- ated with total duration of administration of TW. Conclusion Our data suggest that long-term adminis- tration of TW has remarkable effect on skeletal system in SL E patients,and increases the risk rate of os- teoporosis and bone fracture.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
1998年第1期2-3,共2页
Chinese Journal of Dermatology
关键词
系统性红斑狼疮
雷公藤
中医药疗法
L upus erythematosis,systemic Tripterygium Wilfordii Bone mineral densit
