摘要
目的探讨VEGF在子宫内膜异位症发病中的意义,以及其作为临床诊断指标的可行性,为子宫内膜异位症的临床诊断和治疗提供科学依据和新思路。方法用双抗夹心ELISA法测定各组腹腔液中VEGF水平。结果（1）EMs患者腹腔液中VEGF浓度Ⅰ~Ⅱ期和Ⅲ~Ⅳ期均显著高于对照组（P〈0.01,P〈0.05） 但Ⅰ~Ⅱ期与Ⅲ~Ⅳ期比较差异无统计学意义（P〉0.05）,且VEGF浓度与r-AFS分期无相关性（r=-0.323,P〉0.05）。（2）EMs患者腹腔液中VEGF浓度卵泡期较黄体期显著升高（P〈0.05） 对照组VEGF浓度在卵泡期和黄体期的差异无统计学意义（P〉0.05） 卵泡期腹腔液VEGF浓度在EMs组和对照组间比较,差异有统计学意义（P〈0.01,P〈0.05）,黄体期腹腔液VEGF浓度在EMS组和对照组间比较,差异有统计学意义（P〈0.05）。结论VEGF与子宫内膜异位症的发生、发展有关,EMs患者腹腔液VEGF浓度可能受卵巢激素周期性调节。
Objective To evaluate the significance of VEGF in endometriosis,thereby providing causative and progressive in- formation in its diagnosis and treatment. Methods The concentration of VEGF was studied by enzyme - linked immunosorbent assay （ELISA） . Results （1）The VEGF concentrations in peritoneal fluids of both mild and severe endometriosis groups were significantly higher than that in controls（ P 〈 0.01 ,P 〈 0.05 ）, whereas no significant difference was observed between the mild and severe endome- triosis groups （ P 〉 0.05 ）. There was no correlation between the level of VEGF and degree of endometriosis （ P 〉 0.05 ）. （2）The VEGF concentration in the proliferative phase was significantly higher than that in secretory phase （ P 〈 0.05 ）. （3）A positive correlation be- tween different VEGF levels an peritoneal fluid was observed in the endometriosis group （ P 〈 0.05 ）. Conclusions VEGF is signifi- cantly overexpressed in ectopic endometrium and it may play an important role in the development of endometriosis. The level of VEGF may be adjusted by female hormone.
出处
《武警医学》
CAS
2009年第3期230-232,共3页
Medical Journal of the Chinese People's Armed Police Force
