摘要
采用基于生理学的体外实验,通过模拟人体胃和小肠的环境,分析了胡萝卜中p,p’-DDT,p,p’-DDD和p,p’-DDE在人体胃肠系统的生物有效性.结果表明,DDTs在小肠环境下的生物有效性大于胃环境,胆汁和胰液对生物有效性有正影响;当胡萝卜的质量恒定时,p,p’-DDE,p,p’-DDD和p,p’-DDT在胃和小肠中的生物有效性不随其浓度的变化而变化,它们在胃和小肠中的生物有效性分别为12.72%,12.71%,11.99%和47.14%,41.16%,46.29%.然而,当p,p’-DDT,p,p’-DDD和p,p’-DDE的量恒定时,其生物有效性随胡萝卜质量的增大而减小,且两者之间呈现对数关系.
The bioaccessibility of p,p＇-DDT, p,p＇-DDD and p ,p＇-DDE in the polluted carrot were analyzed using a physiologically based in vitro test by simulating the human gastro-intestinal tract. The study results showed that the bioaccessibilities of p ,p＇-DDT, p ,p＇-DDD and p ,p＇-DDE in intestinal solution were higher than in stomach, and the bile and pancreatin had positive effects to them. When 0. 12 g carrot with different p,p＇-DDE, p,p＇-DDD and p,p＇-DDT concentrations were added and digested in the simulating solution, the bioaccessibility of them were always 12.72%, 12.71% and 11.99% in stomach solution and, 47.14%, 41.16% and 46.29% in intestinal solution, respectively. However, the bioaccessibility of them decreased along with the increasing of the mass of carrot, when the same quality of p, p′-DDT, p,p′-DDD and p,p′-DDE were used. Moreover, distinguish logarithmic correlations were found between the bioaccessibility of DDTs and the mass of carrot.
出处
《环境化学》
CAS
CSCD
北大核心
2009年第2期220-224,共5页
Environmental Chemistry
基金
上海市教委基金项目(06AZ064)
上海高校优秀青年教师后备人选项目
上海市重点学科(S3019)
国家重点基础研究计划项目(2008CB18205)资助
