摘要
为了解前列腺素Ｅ１对先天性心脏病合并肺动脉高压的治疗作用。对２９例先天性心脏病（ＣＨＤ）合并肺动脉高压（ＰＨ）病儿，用前列腺素Ｅ１（ＰＧＥ１）进行治疗。用量为每分钟１００～２００ｎｇ／ｋｇ，每天持续治疗４～５小时，连续用药４～７天。结果：用药后肺内核素计数、动脉血氧饱和度、右心射血指数皆有不同程度的改善。结论：ＣＨＤ合并ＰＨ的病儿，其心（主要是右心）、肺功能皆有异常，应用ＰＧＥ１治疗后可明显改善其心、肺功能，而且用药时间越长。
Aim:This prospective study was conducted to evaluate the effects of Prostaglandin E 1(PGE 1)for patients with congenital heart disease associated with pulmonary hypertension.Clinical material and method:Twenty-nine patients with congenital heart disease associated with pulmonary hypertension underwent open heart surgery under cardiopulmonary bypass.There were 18 boys and 11 girls.The mean age at the operation was 3.3±1.9 years(range,1 to 7 years).Primary heart defects were VSD in 12 patients,VSD+PDA in 6,PDA in 3,DORV in 2,VSD+ASD in 4 and PDA+anomalous of the aortic arch in 2.Continuous intravenous drip of PGE 1 was given at a speed of 100～200ng/kg·min daily for 4 to 7 days before surgery.All patients received radioactive nuclide lung scan before and after treatment with PGE 1.22 patients received Doppler echocardiography and cardiac catheterization before surgery.Arterial oxygen saturation was meansured in 29 patients.Results:The operative mortality rate was 4%(1 of 25).The lung function and arterial oxygen saturation were markedly improved and the right ventricular ejection fraction was increased from 37.2% to 48.2%(3 days treatment)and 59.0%(7 days treatment).Conclusion:Preoperative treatment with PGE 1 can improve patients' cardiopulmonary hemodynamics.The duration of PGE 1 treatment is closely related to its effects.
出处
《中华胸心血管外科杂志》
CSCD
北大核心
1998年第3期142-144,共3页
Chinese Journal of Thoracic and Cardiovascular Surgery
