摘要
目的探讨影响原发性肺癌生存时间的因素，为预测预后提供科学依据。方法选择有病理及细胞学诊断分型的原发性肺癌1272例，定期随访并对死亡病例进行直系亲属调查，两种方法进行入户调查。采用EP12000、SAS软件进行数据的分析，分别计算暴露组和未暴露组的平均生存时间及1年、2年、5年生存情况。结果原发性肺癌的中位生存期为13．67个月，其中男性患者为14．85个月，女性患者为11．90个月，两者有显著性差异（P〈0．01）。男性患者中，吸烟者为14．01个月，不吸烟者为19．62个月，两者比较有显著性差异（P〈0．01）。有结核史者与无结核史者的中位生存期分别为11．76个月和15．30个月，有显著性差异（P〈0．05）。女性患者中，有肿瘤家族史者与无肿瘤家族史者的中位生存期分别为9．01个月和12．50个月，有显著性差异（P〈0．01）。肺癌已手术和未手术者的生存期有显著性差异（P〈0．01）。原发性肺癌的1年生存率为39．40％，2年生存率为14．78％，5年生存率为3．30％。结论影响肺癌生存时间的主要因素为男性吸烟。肿瘤家族史与女性原发性肺癌有关联。结核病仍为影响肺癌生存的重要原因之一。延长肺癌生存时间主要在于手术。吸烟、肿瘤史、结核病史是影响原发性肺癌的生存时间的重要因素。
Objective To explore the factors related to survival time of lung cancer and provide scientific evidence for prognosis. Methods 1217 cases with lung cancer were selected and clinical/pathological data were collected. The patients were followed up. The survival time and survival rate were analyzed by the software Epi2000 and SAS. Results The median overall survival time in lung cancer cases was 13.67 months, with 14.85 months in male and 11.90 months in females（P〈0.01）. The survival rate for one year was only about 39.40%, 14.78% for two years and 3.30% for five years. The analysis showed that smoking was the main factor to influence the survival time of lung cancer in male patients. The family history of tumor was somehow specifically related to the survival in females. Tuberculosis was still an important factor influencing survival of lung cancer patients. The main factor to increase the survival duration was the surgical operation, and the survival duration was two times compared with the non-surgical operation. Conelusions Smoking, the history of tumor and tuberculosis affected the survival time of lung cancer.
出处
《结核病与胸部肿瘤》
2009年第1期35-38,共4页
Tuberculosis and Thoracic Tumor
关键词
肺肿瘤
危险因素
中位生存
ds Lung neoplasms Influencing factors Median overall survival
