摘要
目的研究硫酸奈替米星在大鼠体内分布和排泄情况。方法大鼠ｉｖ给药后，采用高效液相色谱－间接光度检测（ＨＰＬＣ－ＩＰＤ）法测定组织和体液中药物浓度，并计算药动学参数。结果血药浓度－时间曲线符合一室开放模型，不同给药剂量时其体内Ｔ１／２为３．０１～３．６２ｈ；组织中药物浓度以肝、脾、肺、肾中最高，脂肪和脑中较低；平均血浆蛋白结合率为６．８％～１７．４％；尿、粪和胆汁２４ｈ排泄原型药物量占给药量的７４．７％，１．７０％和４．８４％。结论硫酸奈替米星在大鼠体内组织分布具有选择性，蛋白结合率低，主要经肾脏以原型排泄。
AIM To investigate the pharmacokinetic of netilmicin sulfate in rats. METHODS The concentration of netilmicin sulfate was detected by a high performance liquid chromatographyindirect photometric determination (HPLCIPD) method. RESULTS After intramuscutar injection netilmicin sulfate, the data obtained were fitted with 3P87 pharmacokinetic program. The dispostion was conformed to a single compartment model with T1/2=301￣362 h at single dose. The binding percentage of the drug to plasma protein was 68%￣174%. There was a highest drug accumulation in liver, lung and kidney, and a lowest in fat and brain. It excreted in urine, feces and bile within 24 h was 747%, 170% and 484%. CONCLUSION Netilmicin sulfate in rats is noted for its characteristic of distributed in tissues selectively, lower binding percentage to protein and excreted with prototype in kidney mainly.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1998年第2期180-182,共3页
Chinese Pharmacological Bulletin
