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多西他赛联合顺铂治疗转移性乳腺癌疗效分析 被引量：1

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摘要 目的：观察多西他赛联合顺铂治疗经蒽环类药物化疗失败的转移性乳腺癌的疗效及其不良反应。方法：32例蒽环类药物治疗失败的转移性乳腺癌患者进行多西他赛联合顺铂治疗。多西他赛60mg/m2,静滴第一天,顺铂80mg/m2,分三天静脉点滴,每周期评价疗效及不良反应。21天一周期。结果：完全缓解（CR）2例,部分缓解（PR）16例,有效率（CR＋PR）56.2%,主要不良反应为中性粒细胞减少,Ⅲ~Ⅳ度占28.2%,脱发率43.8%。结论：多西他赛联合顺铂是治疗蒽环类耐药的转移性乳腺癌的有效方案,其不良反应可以耐受。
作者 刘小红 杨灵 付浩 李小兵
机构地区 江西省新余市人民医院肿瘤科
出处 《赣南医学院学报》 2009年第1期96-97,共2页 JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词 乳腺癌 化疗 多西他赛 顺铂
分类号 R737.9 [医药卫生—肿瘤]
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参考文献8

  • 1Brodowiezt, Koestler WJ ,Tomeks, et al. Momotherapy with do ce taxel in second-or third-line treatment of anthragycline-resvstant metastatic breast cancer[ J]. Breast Cancer Res Trest, 2004,88:273.
  • 2Vacerov, HocmesFA, WahesRS, et al. phase II trial of docetaxel a new highly effective antineoplastic agent in the management of patients with anthracydine-resistent meta- static hreast cancer[J].J Clin Oneot, 1995,13:2886.
  • 3Sledge GWJr, Loehrer P, JSr RothBJ, et al. cisplaoin as figst-cine therapy for metastatie breast cancer [ J ]. J Clin Oncol, 1988,6 : 1811.
  • 4Sparano JA, Neuberg D, Gliek JH, et al. Phase lltrial of biweakcy Paclitaxel and cisplatin in advanced breast carcinoma An Eastern Cooperatine Oncologg Group stady [J]. J Clin Oncot, 1997,15:1880.
  • 5徐兵河,李凯,刘端琪,李文辉,认宏轩.吉西他滨联合顺铂治疗50例蒽环类耐药性晚期乳腺癌[J].中国癌症杂志,2003,13(6):579-581. 被引量：57
  • 6徐兵河,赵龙妹,王佳玉,袁芃.泰索帝联合顺铂治疗31例蒽环类耐药性晚期乳腺癌疗效分析[J].中华肿瘤杂志,2006,28(6):471-473. 被引量：46
  • 7徐兵河,袁芃,李青,张频,赵龙妹,周际昌.去甲长春花碱联合顺铂治疗晚期乳腺癌的临床疗效[J].中华肿瘤杂志,2001,23(6):521-522. 被引量：50
  • 8徐胜昔 张利群 石颖 等.多帕菲联合顺铂治疗蒽环类耐药的晚期乳腺癌.实用癌症杂志,2006,21:45-45.

二级参考文献16

  • 1[1]Heinemann V. Gemcitabine plus cisplatin for the treatment of metastatic breast cancer[ J]. Clin Breast Cancer,2002,3 (Suppl 1 ): S24-S29.
  • 2[2]Seidman AD. Gemcitabine as single-agent therapy in the management of advanced breast cancer [ J ]. Oncology, 2001,15(2) (Suppl 3): 11-14.
  • 3[3]Jurga L,Misurova E, Kovac V, et al. The role of cisplatin in chemotherapy of advanced breast cancer[J]. Neoplasma, 1994,41 ( 6 ) :347-352.
  • 4[4]Carmichael J, Walling J. Advanced breast cancer:investigational role of gemcitabine[ J]. Eur J Cancer, 1997,33( Suppl 1 ): S27-S31.
  • 5[5]Pegram MD, Lipton A, Hayes DF, et al. Phase Ⅱ study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment [ J ]. J Clin Oncol, 1998, 16(8) :2659-2671.
  • 6[6]Ray-Coquard Ⅰ, Biron P, Bachelot T, et al. Vinorelbine and cisplatin ( CIVIC regimen) for the treatment of metastatic breast carcinoma after failure of anthracycline-and/or paclitaxelcontaining regimens[ J]. Cancer, 1998 ,82 ( 1 ): 134-140.
  • 7[7]Vassilomanolakis M, Koumakis G, Barbounis V, et al.Vinorelbine and cisplatin in metastatic breast cancer patients previously treated with anthracyclines [ J ]. Ann Oncol, 2000,11(5) :1155-1160.
  • 8[8]Moorsel CJ, Veerman G, Bergman AM, et al. Combination chemotherapy studies with gemcitabine[ J]. Semin Oncol, 1997,2,4(2): S7-S23.
  • 9[9]Nagourney RA, Evans SS, Makalinao AJ, et al. Gemcitabine activity in primary cultures of human caner ( Abstract 2161 )[J]. Proc Am Assoc Cancer Res, 1996,37: 318.
  • 10Monica Terenziani,Romano Demicheli,Cristina Brambilla,Laura Ferrari,Angela Moliterni,Milvia Zambetti,Augusto Caraceni,Cinzia Martini,Gianni Bonadonna.Vinorelbine: An active, non cross-resistant drug in advanced breast cancer. Results from a phase II study[J].Breast Cancer Research and Treatment.1996(3)

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赣南医学院学报
2009年 第1期

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