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TRAIL分子靶点在肺癌治疗中的研究及应用 被引量：3

Research Advance of TRAIL Molecular Target in the Therapy of Lung Cancer
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摘要 目前肺癌的发病率在全球范围内呈持续上升的趋势。在中国，肺癌的发病率和死亡率在所有肿瘤中是最高的。肺癌患者中，只有30％的非小细胞肺癌可以通过外科手术切除，但手术后5年存活率很低，生活质量也不高，晚期不能手术的患者通常只能采用常规化疗或放疗，毒副作用大，疗效不理想。因此，寻找新的肺癌治疗手段是目前亟待解决的难题。
作者 刘乾 马玲娣 王勇
机构地区 南京医科大学附属常州第二人民医院中心实验室 南京医科大学附属常州第二人民医院胸外科
出处 《中国肺癌杂志》 CAS 2009年第3期252-255,共4页 Chinese Journal of Lung Cancer
基金 江苏省自然科学基金(No.BS2007025)资助~~
关键词 肺癌患者 TRAIL 分子靶点 治疗 外科手术切除 非小细胞肺癌 5年存活率 生活质量
分类号 R734.2 [医药卫生—肿瘤] R392.11 [医药卫生—免疫学]
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参考文献22

  • 1Wiley SR, Schooley K, Smolak PJ. Identification and characterization of a new member of the TNF family that induees apoptosis. Immunity, 1995, 3(6): 673- 682.
  • 2Pan G, O'Rourke K, Chinnaiyan AM, et al. The receptor for the cytotoxic ligand TRAIL. Science, 1997,276(5309): 111-113.
  • 3Pan G, Ni J, Wei YF, et al. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science, 1997, 277(5327): 815-818.
  • 4Marsters SA, Sheridan JP, Pitti RM, et al. A novel receptor for Apo2L/ TRAIL contains a truncated death domain. Curr Biol, 1997, 7(12): 1003-1006.
  • 5Emery JG, McDonnell P, Burke MB, et al. Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. J Biol Chem, 1998, 273(23): 14363-14367.
  • 6Trabzuni D, Famulski KS, Ahmad M. Functional analysis of tumor necrosis factor-ct-related apoptosis-inducing ligand (TRAIL): cysteine-230 plays a critical role in the homotrimerization and biological activity of this novel tumoricidal cytokine. Biol Chem, 2000, 350(2): 505-510.
  • 7Buchsbaum D J, Zhou T, Lobuglio A F, et al. TRAIL receptor-targeted therapy. Future Oncol, 2006, 2(4): 493-508.
  • 8Zhang L, Fang B. Mechanisms of resistance to TRAIL-induced apoptosis in cancer. Cancer Gene Ther, 2005, 12(3): 228-237.
  • 9Ki M Kim, Yong J Lee. Amiloride augments TRAIL-induced apoptotic death by inhibiting phosphorylation of kinases and phosphatases associated with the P13K-Akt pathway. Oncogene, 2005, 24(22): 355-366.
  • 10Puduvalli VK, Sampath D, Bruner JM, et al. TRAIL-induced apoptosis in gliomas is enhanced by Akt-inhibition and is independent of JNK activation. Apoptosis, 2005, 10(1): 233-243.

二级参考文献28

  • 1Xiao-Chao Wei Xin-Juan Wang Kai-Chen Lei Zhang Yu Liang Xin-Li Lin Department of Biochemistry and Molecular Biology,Peking University Health Science Center,Beijing 100083,ChinaProtein Studies,Oklahoma Medical Research Foundation,Oklahoma City,OK 73104,USA.Killing effect of TNF-related apoptosis inducing ligand regulated by tetracycline on gastric cancer cell line NCI-N87[J].World Journal of Gastroenterology,2001,7(4):559-562. 被引量：11
  • 2Wiley SR, Schooley K, Smolak PJ, et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity,1995,3(6):673-682.
  • 3Odoux C, Albers A, Amoscato AA, et al. TRAIL, FasL and a blocking anti-DR5 antibody augment paclitaxel-induced apoptosis in human non-small-cell lung cancer. Int J Cancer,2002,97(4):458-465.
  • 4Keane MM, Ettenberg SA, Nau MM, et al. Chemotherapy aug-ments TRAIL-induced apoptosis in breast cell lines. Cancer Res,1999,59(3):734-741.
  • 5Lacour S, Hammann A, Wotawa A, et al. Anticancer agents sensitize tumor cells to tumor necrosis factor-related apoptosis-inducing ligand-mediated caspase-8 activation and apoptosis. Cancer Res,2001,61(4):1645-1651.
  • 6Aggarwal BB, Bhardwaj U, Takada Y. Regulation of TRAIL-induced apoptosis by ectopic expression of antiapoptotic factors. Vitam Horm,2004,67:453-483.
  • 7Spierings DC, de Vries EG, Timens W, et al. Expression of TRAIL and TRAIL death receptors in stage Ⅲ non-small cell lung cancer tumors. Clin Cancer Res,2003,9(9):3397-3405.
  • 8Abou El Hassan MA, Mastenbroek DC, Gerritsen WR, et al. Overexpression of Bcl2 abrogates chemo- and radiotherapy-induced sensitisation of NCI-H460 non-small-cell lung cancer cells to adenovirus-mediated expression of full-length TRAIL. Br J Cancer,2004,91(1):171-177.
  • 9Yamanaka T, Shiraki K, Sugimoto K, et al. Chemotherapeutic agents augment TRAIL-induced apoptosis in human hepatocellular carcinoma cell lines. Hepatology,2000,32(3):482-490.
  • 10Liu W, Bodle E, Chen JY, et al. Tumor necrosis factor-related apo-ptosis-inducing ligand and chemotherapy cooperate to induce apoptosis in mesothelioma cell lines. Am J Respir Cell Mol Biol,2001,25(1):111-118.

共引文献9

同被引文献7

引证文献3

二级引证文献6

中国肺癌杂志
2009年 第3期

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