摘要
目的:建立高效液相色谱法测定盐酸布桂嗪注射液中的有关物质。方法:采用C18柱,以甲醇-0.1mol·L-1醋酸铵溶液(用氨试液调节pH值至7.0)(75∶25)为流动相,检测波长为252nm。结果:盐酸布桂嗪与其降解产物在该色谱条件下能够有效分离。结论:方法简便、专属性强,可用于测定盐酸布桂嗪注射液中有关物质。
Objective：To establish an HPLC method for determining related substance in Bucinnazine Hydrochloride Injections. Methods： Using HPLC with C18 column, methanol -0. 1 mol · L-1 ammonium acetate solution （adjusted to pH 7.0 with ammonia solution） （75：25） as mobile phase and the detection wavelength at 252 nm. Results： Bucinnazine Hydrochloride and its related substance can be separated effectively by this method. Conclusion： The method is simple and reliable. Related substance in Bucinnazine Hydrochloride Injections can be determined by HPLC.
出处
《中国药品标准》
CAS
2009年第1期44-46,共3页
Drug Standards of China
关键词
HPLC法
盐酸布桂嗪
有关物质
HPLC
Bucinnazine Hydrochloride Injections
Related Substance
