摘要
目的:观察三七粉对小鼠S180移植肿瘤的抑制作用及免疫功能的影响,为寻找有效和低毒的抗肿瘤药物提供有价值的实验资料。方法:建立小鼠S180腹水瘤及实体瘤模型,分别设羧甲基纤维素钠(SCMC)组、环磷酰胺(CTX)组及三七粉低(3 mg/kg)、中(6 mg/kg)、高(12 mg/kg)剂量组。观察腹水瘤小鼠生存时间,计算生命延长率;测实体瘤小鼠瘤重、脾重及胸腺重,计算抑瘤率、脾指数及胸腺指数。各组比较并进行统计学分析。结果:与SCMC组比较,三七粉中、高剂量组及CTX组生存时间均延长(P<0.05～P<0.01),瘤体均缩小(P<0.05～P<0.01);与SCMC组及CTX组比较,三七粉中、高剂量组脾指数和胸腺指数均升高(P<0.05～P<0.01)。结论:三七粉对小鼠S180移植肿瘤具有抑制作用,并可增强荷瘤小鼠的免疫功能。
Objective：To observe the inhibitory effects of sanchi powder on the growth of tumor and the influence of immunologic function on sarcoma 180 （S180 hearing mice, and to supply experimental data for the research of high efficiency and low toxicity antitumor drugs. Methods： The models of S180 ascitic tumor and solid tumor were established and divided respectively into sodium carboxymethycellulose （SCMC） group, cyclophosph-amide （ CTX ） group and sanehi powder of low （ 3 mg/kg） , middle （ 6 mg/kg） and high （12 mg/kg） groups;then the life span and the life extension rate of the mice with ascitic tumor were observed. The weight of the tumor, spleen, and thymus was measured;the antitumor rate,indexes of spleen and thymus of the mice with solid tumor were caculated; the statistical analysis was made among the groups. Results： Compared with the SCMC group, the survival rates of the middle and high dose sanchi powder groups and CTX group increased （ P 〈 0. 05 - P 〈 0. 01 ） and the tumor weight decreased （ P 〈 0. 05 - P 〈 0.01 ）. Compared with the SCMC group and CTX group, the indexes of spleen and thymus of both the middle and high dose sanchi powder groups increased（ P 〈 0.05 - P 〈 0.01 ）. Conclusions： Sanchi powder has inhibitory effects on the growth of transplanted tumor and may enhance the immunologic function of S180 bearing mice.
出处
《蚌埠医学院学报》
CAS
2009年第3期195-197,共3页
Journal of Bengbu Medical College
关键词
肿瘤
实验性
肿瘤/药物疗法
三七
腹腔积液
免疫功能
小鼠
肉瘤180
neoplasms, experimental
neoplasms/drug therapy
Panax notoginseng sanehi
seroperitoneum
immunologic function
mice
sarcoma 180
