摘要
目的：探讨谷胱甘肽过氧化物酶与牙周组织病的关系。方法：选择了１２例慢性龈炎，１３例单纯性牙周炎，９例健康对照，采用ＤＴＮＢ显色法测定酶的活性，对其病变龈组织做ＧＳＨ－ＰＸ测定，并分析了临床指标与实验室指标的相关关系。结果：１．龈炎组，ＧＳＨ－ＰＸ含量为２９３．７４±１２１．７０，牙周炎组为２４２．９７±１１０．５９，对照组７８１．２５±１１３．３９，龈炎组、牙周炎组的ＧＳＨ－ＰＸ活性显著低于对照组（Ｐ＜０．０１），龈炎组与牙周炎组ＧＳＨ－ＰＸ活性无显著差异（Ｐ＞０．０５）。２．龈炎组牙龈指数与ＧＳＨ－ＰＸ活性成负相关（ｒ＝－０．７２２５，Ｐ＜０．００５），牙周炎组牙周袋深度，附着丧失量与ＧＳＨ－ＰＸ活性成负相关（ｒ＝－０．７６５３，ｒ＝－０．８５７８，Ｐ＜０．００２５）。结论：牙周病变组织ＧＳＨ－ＰＸ活性降低可能有两方面的原因，其一是牙周病是细菌引起的非特异性炎症，由于细菌的存在，局部自由基生成增多对ＧＳＨ－ＰＸ消耗增大；其二是由于全身因素的影响局部ＧＨＳ－ＰＸ合成减少。
Objective:To study the relation between glutethionl peroxidase(GSH PX) level and periodontal diseases. Methods:The activity of GSH PX was measured in gingival tissue from 25 patients and 9 healthy control was measured with DTNB staining technic. Results:1. The levels of GXH PX were 293.74±121.70,242.97±110.59 and 781.25±113.39 unit in gingival tissue with chronic gingivitis, periodontitis and control, respectively ( P >0.05 between control and chronic gingivitis or periodontitis; P <0.05 between chronic gigivitis and periodontitis).2. Gingival Index(GI) was negatively correlated with GXH PX activity in gingivitis ( r =-0.7225, P <0.005). periodontal pocket deepth(PD) or attachment loss(AL) with the activity of GSH PX periodontitis(( r =-0.7665 or r =-0.8578, P >0.025). Conclusion: Reduction of GXH PX in the diseased tissues may be caused by increased comsumption of GSH PX for more free radicals produced and by decreased synthesis of GSH PX through systematic influence.
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
1998年第1期11-13,共3页
Journal of Practical Stomatology
