摘要
目的观察卡培他滨联合奥沙利铂(L-OHP)治疗晚期胃癌的的临床疗效和毒副反应。方法经病理学或细胞学确诊的54例晚期患者,应用卡培他滨1250mg/m2口服,第1～14天,L-OHP85mg/m2,静滴2h,dl、d15;28d为1周期,至少2个化疗周期后观察疗效及其不良反应。结果可评价疗效者52例;CR1例(1.92%),PR28例(53.85%),SD13例(25%),PD10例(19.23%),总的有效率(RR)达55.77%。中位肿瘤进展时间(TTP)5.3(2～13)月,毒副反应主要为手足综合征、胃肠道反应、骨髓抑制和黏膜炎等,多为I～Ⅱ度毒性反应,对症治疗或停止治疗后可缓解,无化疗相关死亡者。结论XELOX方案在晚期胃癌的治疗中疗效较为肯定,且耐受性良好。
Objective To evaluate the efficacy and toxicity of capecitabine in combination with oxaliplatin regimen（XELOX）as the adjuvant chemotherapy in the treatment of patients with advanced gastric cancer.Methods Fifty-four patients with advanced gastric cancer were enrolled in the study.XELOX regimen（oxaliplatin 85 mg/m2 in 2-hour infusion on Dl and D15,capecitabine l250mg/m2/d divided in two daily doses given from D1 to D14）was adopted.The cycles were repeated every 28 days.All patients received two or more cycles.Results Fifty-two patients were evaluable for efficacy and toxicity,totally 199 cycles.The overall response rate was 55.77%（including 1 CR,28 PR,13 SD and 10 PD）.The time to tumor progression（TTP）was 2 to l3 months（median 5.3 months）.Therapy was generally well tolerated,and the most common adverse effects were hand-foot syndrome,gastrointestinal response and bone marrow suppression.There was no chemotherapy related death.Conclusion XELOX regimen is an effective and well-tolerated chemotherapy regimen for advanced gastric cancer.
出处
《中国现代医药杂志》
2009年第1期53-55,共3页
Modern Medicine Journal of China
关键词
卡培他滨
奥沙利铂
晚期胃癌
Capecitabine Oxaliplatin Advanced gastric cancer
