摘要
在酵母诱导的发热大鼠中，桂枝汤有效部位Ａ可使下丘脑前列腺素Ｅ２（ＰＧＥ２）水平下降；在安痛定诱导的低体温大鼠，则使ＰＧＥ２水平升高。
Effect of Fr.A,active fractive A isolated from Guizhi decoction, on inositol 1,4,5 triphosphate (IP3) and calmodulin (CaM) in hypothalamus in yeastinducted febrile rats and aminopyrineinduced hypothermal rats was studied. The results showed that IP3 and CaM contents were significantly decreased in febrile rats,and markedly increased in hypothermal rats. Theose values were reversed to almost normal level in both models after administration of Fr.A. The results suggest that IP3 and CaM in the thermoregulatory center take part in the dualdirectional regulation of Fr.A.
出处
《中国实验方剂学杂志》
CAS
1998年第2期25-28,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金
关键词
桂枝汤
体温双向调节
三磷酸肌醇
钙调蛋白
Active fraction A of Guizhi decoction,Dualdirectional thermoregulation,inositol 1,4,5 triphosphate,calmodulin
