摘要
目的研究材料羟基磷灰石复合人工骨（HA／UHMWPE）和高密度多孔聚乙烯（HDPE）行兔眶骨缺损后修补的组织相容性和骨传骨性，为临床眶壁重建材料的选择及应用提供实验依据。方法对60只日本大耳兔随机分成3纽，每组20只，分为1、2、4、8周四个实验点。动物行眶上缘骨缺损，组1植入HDPE，组2植入HA／UHMWPE板块材料，组3作为对照组不植入材料，术后1、2、4、8周取材，每个实验点均行材料内碱性磷酸酶检测及骨钙索分离与定量检测。结果HDPE材料与骨缺损的愈合程度要强于HA／UHMWPE，所有材料未见感染，移位以及脱出等排斥反应。两种材料中碱性磷酸酶以及骨钙素含量有较大差异，HDPE组要优于HA／UHMWPE组，差异具有统计学意义（P〈0．05）。结论两种材料均具有较好的组织相容性，HDPE材料较HA／UHMWPE有较好的骨传导特征。
Objective To compare the biocompatible and osteconduction behavior of the high-density porous polyethylene and hydroxyapatite/ultra-high molecular weight polyethylene. Methods Osteoeetomy of the upper orbital rim was performed on 60 adult Japan rabbits. The animals were randomly divided into 3 groups with 20 of each. The hydroxyapatite/ultra-high molecular weight polyethylene, high-density porous polyethylene was implanted to the upper orbital defect of the animals in respective group. Animals were sacrificed at the 1st, 2nd, 4th and 8th weeks. Alkaline phosphatase （ALP） and Osteocalcin （OC）in the HDPE and hydroxyapatite/ultra-high molecular weight polyethylene was also detected. Result During the experimental period of 8 weeks, there was no implants extrusion or displacement. Fibrous tissue and new vessels grew into HDPE were obviously elder than those grew into hydroxyapatite/uhra high molecular weight polyethylene. Alkaline phosphatase and osteocalcin contents has great difference, HDPE group is the best, followed by HA combination artificial group （ P 〈 0. 05 ）. Conclusions High-density porous polyethylene and hydroxyapatite/ultra-high molecular weight polyethylene are both good orbital reconstruction materials, they all have good biocompatiblity and osteoconduction, but high-density porous polyethylene is better than hydroxyapatite/uhra-high molecular weight polyethylene in osteoconduction.
出处
《中国医师杂志》
CAS
2009年第2期205-207,共3页
Journal of Chinese Physician
