摘要
目的:探讨增龄对大鼠阴茎组织中内源性一氧化碳(CO)与环磷酸鸟苷(cGMP)、环磷酸腺苷(cAMP)含量的变化。方法:8、16、24个月大鼠各8只,分别注射阿朴吗啡(APO)进行大鼠阴茎勃起功能实验;麻醉后取阴茎海绵体,用改良双波长分光光度法测量其CO浓度,并测量其cAPM、cGMP含量。结果:随月龄增加,CO含量降低,各月龄组间差异有显著性(P均<0.01);cGMP、cAMP含量均随月龄增加而逐渐下降,各月龄组间差异有显著性(P均<0.01)。结论:随月龄的增加,大鼠阴茎组织中CO、cAMP、cGMP含量下降,提示衰老对大鼠阴茎组织中CO、cAMP、cGMP含量影响显著。
Objective： To explore the relationship of aging with the changes of endogenous carbon monoxide （ CO）, cGMP and cAMP contents in the penile tissues of rats. Methods ： Twenty-four male rats were equally divided into an 8-mouth, a 16-month and a 24- month group, and their penile erection was detected by injecting apomorphine, their penile cavernous body harvested, and the contents of CO, cAPM and cGMP detected by improved dual wavelength spectrophotometry. Results ： The contents of CO, cAPM and cGMP were reduced with the increase of age, with statistically significant differences between the three age groups （ P 〈 0.01 ）. Conclusion： Aging significantly decreased the contents of CO, cAMP and cGMP in the penile tissues of the rats, which suggests that aging might play an important role in erectile dysfunction.
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2009年第2期122-125,共4页
National Journal of Andrology
基金
黑龙江省自然科学基金(D2005-08)
黑龙江省卫生厅重点项目(2007-499)~~
