摘要
应用Ｆｕｒａ２ＡＭ荧光探针研究了低剂量Ｘ射线照射后２４ｈ昆明鼠胸腺细胞游离钙浓度的变化。结果表明：７５ｍＧｙ全身照射后胸腺细胞［Ｃａ２＋］ｉ明显高于对照组，而加入次佳浓度的ＣｏｎＡ则使［Ｃａ２＋］ｉ较单纯照射更明显增高。提示低剂量辐射可促进Ｔ淋巴细胞的信号传递。
Kunming mice were whole body irradiated with different doses of X rays. Changes of cytosolic free calcium concentration in thymocytes were measured using Fura 2AM as fluorescent probe. It was found that [Ca 2+ ] i increased 24 h after WBI with 75～100 mGy X rays. and the increase in [Ca 2+ ] i of thymocytes was fonud to be more marked in the presence of ConA stimulation. The results indicate that low dose radiation can promote signaltransduction of T lymphocytes.
出处
《辐射研究与辐射工艺学报》
CAS
CSCD
北大核心
1998年第1期42-44,共3页
Journal of Radiation Research and Radiation Processing
基金
国家自然科学基金
关键词
低剂量
电离辐射
胸腺细胞
信号传递
游离钙
Low dose radiation, Thymocyte, Cytosolic free calcium concentration, Signal transmission, Fura 2AM
