摘要
[目的]探讨芪术建中汤治疗脾阳虚胃溃疡的部分作用机理,客观阐明芪术建中汤的科学内涵。[方法]用SD大鼠60只,随机分正常/空白对照组、模型组、硫糖铝组、芪术建中汤大剂量组、芪术建中汤中剂量组、芪术建中汤小剂量组。除正常对照组外均采用饮食失节、劳倦失常加苦寒泻下法以及冷水刺激法建立脾阳虚胃溃疡大鼠模型。各组分别用药治疗后,测定大鼠血清中IL-6和血清GAS的水平,并应用光镜观察胃粘膜的病理变化。[结果]与正常对照组相比,脾阳虚胃溃疡模型组大鼠血清中IL-6升高、GAS水平下降;与脾阳虚胃溃疡模型组比较,使用硫糖铝、芪术建中汤高、中剂量均能显著降低脾阳虚胃溃疡模型大鼠血清中IL-6水平,升高GAS水平,差异显著(P<0.01);而芪术建中汤低剂量组则与脾阳虚胃溃疡模型组无明显差异(P>0.05)。光镜结果显示芪术建中汤高剂量组、中剂量组、硫糖铝组胃黏膜损伤程度均轻于脾阳虚胃溃疡模型组,而芪术建中汤低剂量组胃黏膜损伤程度则与脾阳虚胃溃疡模型组相仿。[结论]芪术建中汤高、中剂量组均对脾阳虚胃溃疡有显著治疗作用,而芪术建中汤低剂量组则对脾阳虚胃溃疡无显著治疗作用。
[Objective] To explore part of mechanism of Qizhu Jianzhong Decoction treating gastric ulcer and spleen Yang deficiency, impersonally state the scientific connotation of the decoction. [Method] Randomly divide 60 SD rats into normal/ blank control group（ Ⅰ ）, model group（ Ⅱ ） , sucralfate group（ Ⅲ） , large-dosage group（ Ⅳ ）, middle dosage group（ Ⅴ ） and small-dosage group （Ⅵ） of Qizhu Jianzhong Decoction. Except for the group Ⅰ , others are made into rats model of spleen yang deficiency and gastric ulcer with abnormal diet, fatigue, cold and bitter purgation, and cold water stimulant. After being administered medicines, meas- ure their IL-6 and GAS level, and observe the pathological changes of gastric mucosa under microscope. [Result] Compared with group Ⅰ , in the model group, the IL-6 rose, GAS decreased; compared with the model group, other groups of Ⅲ, Ⅳ and Ⅴ all markedly decreased rats serum Ⅱ- 6 level and increased GAS level, with obvious difference（P〈0.01）;while there＇s no marked difference between groups Ⅵ and Ⅱ （P〉0.05）. Under microscope, the gastric mueosa injury degree was less in groups Ⅲ , Ⅳ and Ⅴ than group Ⅱ ; and it was similar between group Ⅵ and group Ⅱ. [Conclusion] Groups Ⅳ and Ⅴ have marked cure effect on spleen yang deficiency and gastric ulcer, and group Ⅵ has no obvious cure effect.
出处
《浙江中医药大学学报》
CAS
2009年第1期40-42,共3页
Journal of Zhejiang Chinese Medical University
关键词
芪术建中汤
脾阳虚胃溃疡
IL-6
GAS
SD大鼠
Qizhu Jianzhong Decoction
spleen yang deficiency gastric ulcer
IL-6
GAS
SD rats
