摘要
目的探讨瘤内注射胶体^(32)磷治疗肝癌的可行性。方法送肿瘤及各主要脏器作病理检查,查肝、肾功能及血常规,则A组大鼠胶体^(32)磷的体内分布。结果胶体^(32)磷注射后主要聚集于肿瘤及其邻近肝区,除第7天有一过性ALT增高外,未见其它毒副作用。治疗后肿瘤体积缩小,生长率降低,与B组(30天时)及C组比较差异有显著意义(P<0.01)。结论瘤内注射胶体^(32)
Objective To explore the feasibility of P-32-colloid injected directly into tumors for the treatment of liver cancer. Methods Pathologic examination of the tumor and main organs, and the determination of liver and renal functions and routine blood test were performed. The P-32-colloid biodistribution was mea- surcd. Results Injected P-32-colloid mainly concentrated in the tumor and its periphery. Besides transient elevated ALP, no any toxicity and adverse reaction was observed. After treatment, the lesion was reduced in size, the growth rate of tumor decrcaed. There was a significant difference between group B (30th day) and control group (P<0.01). Conclusion Intratumor injection of P-32-colloid is a safe, fcasible and effective method to treat liver cancer.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
1998年第1期21-22,共2页
Chinese Journal of Experimental Surgery
关键词
肝肿瘤
注射疗法
胶体磷32
P-32-colloid Liver cancer Intratumor injection
